Linked Life Data

7542643

Source:http://linkedlifedata.com/resource/pubmed/id/7542643

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-8-28
pubmed:abstractText
Lipopolysaccharide (LPS) or endotoxin elicits a broad, non-specific cascade of events in vivo, resulting in secretion of a variety of potent mediators and cytokines produced primarily by activated macrophages and monocytes. The overproduction of these effector molecules, such as interleukin-1 and tumor necrosis factor-alpha, contributes to the pathophysiology of endotoxic shock. Cellular recognition of LPS involves several different molecules, including cluster of differentiation antigen CD14. A thorough understanding of the interaction of LPS with cells of the immune system is necessary before effective preventative or therapeutic measures can be designed to limit the host response to endotoxin. This review discusses the role of CD14 and other LPS-recognition molecules in LPS-mediated macrophage activation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0162-3109
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
187-205
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
CD14 and other recognition molecules for lipopolysaccharide: a review.
pubmed:affiliation
Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan 66506, USA.
pubmed:publicationType
Journal Article, Review