Linked Life Data

7541635

Source:http://linkedlifedata.com/resource/pubmed/id/7541635

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1995-8-11
pubmed:abstractText
In neurons, tubulin is synthesized only in the cell body or dendrites, yet the growing axon requires a steady supply of this protein at the growth cone. Hence, some mechanism must exist to move tubulin from the cell body to the growth cone. Transport could conceivably occur by simple diffusion, translocation of polymer, or some form of monomer or oligomer transport. Evidence for all these has been presented in a variety of experimental systems. We have directly studied the movement of microtubules in 12 growing axons in live grasshopper Ti1 neurons in their natural environment by labeling the polymer with a caged fluorophore, biscaged fluorescein. No evidence of polymer transport was found. Hence, tubulin movement in these neurons must occur by movement of monomeric tubulin, either by transport or diffusion. To resolve these conflicting views, we discuss the conditions under which diffusion is feasible as a transport mechanism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0896-6273
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1247-56
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Axonal transport of tubulin in Ti1 pioneer neurons in situ.
pubmed:affiliation
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
pubmed:publicationType
Journal Article