|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1995-8-11
|
|
pubmed:abstractText |
The receptor mechanisms mediating the retrograde axonal transport of the neurotrophins have been investigated in adult rats. We show that transport of the TrkB ligands NT-4 and BDNF to peripheral neurons is dependent on the low affinity neurotrophin receptor (LNR). Pharmacological manipulation of LNR in vivo using either an anti-LNR antibody or a soluble recombinant LNR extracellular domain completely blocked retrograde transport of NT-4 and BDNF to sensory neurons, while having minimal effects on the transport of NGF in either sensory or sympathetic neurons. Furthermore, in mice with a null mutation of LNR, the transport of NT-4 and BDNF, but not NGF, was dramatically reduced. These observations demonstrate a selective role for LNR in retrograde transport of the various neurotrophins from distinct target regions in vivo.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Brain-Derived Neurotrophic Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Ciliary Neurotrophic...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Nerve Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Nerve Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neuropeptide,
http://linkedlifedata.com/resource/pubmed/chemical/Wheat Germ Agglutinins,
http://linkedlifedata.com/resource/pubmed/chemical/neurotrophin 4
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0896-6273
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
14
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
N
|
|
pubmed:pagination |
1201-11
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:7541633-Animals,
pubmed-meshheading:7541633-Axonal Transport,
pubmed-meshheading:7541633-Binding Sites,
pubmed-meshheading:7541633-Biological Transport,
pubmed-meshheading:7541633-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:7541633-Ganglia, Spinal,
pubmed-meshheading:7541633-Humans,
pubmed-meshheading:7541633-Male,
pubmed-meshheading:7541633-Mice,
pubmed-meshheading:7541633-Mice, Inbred BALB C,
pubmed-meshheading:7541633-Motor Neurons,
pubmed-meshheading:7541633-Mutation,
pubmed-meshheading:7541633-Nerve Growth Factors,
pubmed-meshheading:7541633-Nerve Tissue Proteins,
pubmed-meshheading:7541633-Neurons, Afferent,
pubmed-meshheading:7541633-Rats,
pubmed-meshheading:7541633-Rats, Sprague-Dawley,
pubmed-meshheading:7541633-Receptor, Ciliary Neurotrophic Factor,
pubmed-meshheading:7541633-Receptor, Nerve Growth Factor,
pubmed-meshheading:7541633-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:7541633-Receptors, Nerve Growth Factor,
pubmed-meshheading:7541633-Receptors, Neuropeptide,
pubmed-meshheading:7541633-Wheat Germ Agglutinins
|
|
pubmed:year |
1995
|
|
pubmed:articleTitle |
Differential role of the low affinity neurotrophin receptor (p75) in retrograde axonal transport of the neurotrophins.
|
|
pubmed:affiliation |
Regeneron Pharmaceuticals, Inc., Tarrytown, New York 10591, USA.
|
|
pubmed:publicationType |
Journal Article
|
