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| pubmed-article:7541426 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:7541426 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:7541426 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:7541426 | lifeskim:mentions | umls-concept:C2698651 | lld:lifeskim |
| pubmed-article:7541426 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:7541426 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:7541426 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:7541426 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7541426 | pubmed:dateCreated | 1995-8-7 | lld:pubmed |
| pubmed-article:7541426 | pubmed:abstractText | Efficient initiation of a CD4 T cell response requires both activation through the TCR and costimulation provided by molecules on APC with counterreceptors on the T cell. We investigated the relative contribution of the ICAM-1:LFA-1 and B7:CD28/CTLA-4 costimulatory pathways in naive T cell activation, using either anti-CD28 Ab or fibroblast cell lines transfected with I-Ek, which express either no costimulatory molecules, ICAM-1 alone, B7-1 alone, or ICAM-1 and B7-1 together. Peptide Ag or immobilized anti-CD3 was used to provide the TCR signal. CD4 T cells from mice transgenic for the V beta 3/V alpha 11 TCR, which recognize a peptide of pigeon cytochrome c complexed to I-Ek, were used as a source of naive T cells. Naive T cells stimulated with Ag or anti-CD3 responded well to high numbers of APC expressing either ICAM-1 alone or B7-1 alone. However, APC expressing both ICAM-1 and B7-1 were much better stimulators of proliferation and IL-2 secretion at low cell numbers, and were far superior inducers of IL-2 at higher numbers, indicating a synergy between the two pathways. Stimulation provided by ICAM-1 could not be solely attributed to adhesive strengthening of other pathways, since costimulation was seen when immobilized anti-CD3 was used and when ICAM-1 only APC were added, indicating that ICAM-1 was in fact acting as a classic costimulatory molecule. Both the magnitude of the response and the amount of costimulation required for response were dependent on the intensity of TCR interaction. These results suggest that an efficient naive T cell response requires both a strong TCR signal and more than one costimulatory signal that will synergize with the TCR signal. This offers an explanation as to why APC such as dendritic cells and activated B cells, which express high levels of multiple costimulatory/adhesion molecules, are the only APC that elicit naive T cell responses. | lld:pubmed |
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| pubmed-article:7541426 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7541426 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7541426 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7541426 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:7541426 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7541426 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7541426 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:7541426 | pubmed:author | pubmed-author:SwainS LSL | lld:pubmed |
| pubmed-article:7541426 | pubmed:author | pubmed-author:CroftMM | lld:pubmed |
| pubmed-article:7541426 | pubmed:author | pubmed-author:DubeyCC | lld:pubmed |
| pubmed-article:7541426 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7541426 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7541426 | pubmed:volume | 155 | lld:pubmed |
| pubmed-article:7541426 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7541426 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7541426 | pubmed:pagination | 45-57 | lld:pubmed |
| pubmed-article:7541426 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:7541426 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7541426 | pubmed:articleTitle | Costimulatory requirements of naive CD4+ T cells. ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response. | lld:pubmed |
| pubmed-article:7541426 | pubmed:affiliation | Department of Biology, University of California, at San Diego, La Jolla 92093, USA. | lld:pubmed |
| pubmed-article:7541426 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7541426 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7541426 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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