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rdf:type |
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lifeskim:mentions |
umls-concept:C0003316,
umls-concept:C0017262,
umls-concept:C0033684,
umls-concept:C0039195,
umls-concept:C0085358,
umls-concept:C0449450,
umls-concept:C0547040,
umls-concept:C1171362,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1515670,
umls-concept:C1519889,
umls-concept:C1522240,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
13
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pubmed:dateCreated |
1995-8-3
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pubmed:abstractText |
The epitopes recognized by CD8+ cytotoxic T lymphocytes (CTL) are generated from cytosolic proteins by proteolytic processing. The nature of the influences exerted by the sequences flanking CTL epitopes on these processing events remains controversial. Here we show that each epitope within an artificial polyepitope protein containing nine minimal CD8+ CTL epitopes in sequence was processed and presented to appropriate CTL clones. Natural flanking sequences were thus not required to direct class I proteolytic processing. In addition, unnatural flanking sequences containing other CTL epitopes did not interfere with processing. The ability of every CTL epitope to be effectively processed from a protein containing only CTL epitopes is likely to find application in the construction of recombinant polyepitope CTL vaccines.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-1299222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-1317508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-1377222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-1377517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-1383384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-1436094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-15335818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-1690855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-1715994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-1722774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-1732413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-1875170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-1913805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-2453800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-2462610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-2744487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-3029399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-3943125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-4029620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-7511684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-7521064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-7521394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-7523572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-7677954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-7677956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-7689619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-8066463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-8107849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-8144958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-8371781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-8389422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-8396732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-8456302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7541138-8510226
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Epstein-Barr Virus Nuclear Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Synthetic,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Vaccines
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5845-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7541138-Humans,
pubmed-meshheading:7541138-Vaccinia virus,
pubmed-meshheading:7541138-Epitopes,
pubmed-meshheading:7541138-Viral Vaccines,
pubmed-meshheading:7541138-Amino Acid Sequence,
pubmed-meshheading:7541138-Clone Cells,
pubmed-meshheading:7541138-Antigens, Viral,
pubmed-meshheading:7541138-Molecular Sequence Data,
pubmed-meshheading:7541138-Epstein-Barr Virus Nuclear Antigens,
pubmed-meshheading:7541138-HLA Antigens,
pubmed-meshheading:7541138-Vaccines, Synthetic,
pubmed-meshheading:7541138-DNA-Binding Proteins,
pubmed-meshheading:7541138-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:7541138-Drug Design,
pubmed-meshheading:7541138-HLA-A Antigens
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