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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1995-7-28
|
| pubmed:abstractText |
Schistosome antigens selected as vaccine candidates should induce in the majority of humans T and B cell-mediated immunity that results in protection against infection. As a first step towards the identification of such antigens, we attempted to define and characterize the soluble adult Schistosoma mansoni worm antigen (SAWA) bands that are recognized by serum antibodies and/or peripheral blood mononuclear cells of Egyptian children with early active S. mansoni and/or S. haematobium infection. Considerable inter-subject variation was observed in the SAWA bands recognized by antibodies and T lymphocytes, as demonstrated by Western blotting and T cell Western assays, respectively. The humoral response rate for the separated SAWA bands varied between 0% and 88% of infected subjects. The bands of 153, 144, 38 and 32 kDa reacted with the sera of 60 to 88% of infected subjects but not with the sera of uninfected controls. The bands of 144, 38, 32 and 18 kDa elicited proliferative responses in the lymphocytes of 42-63% of infected subjects. It was thus concluded that the SAWA bands of 144, 38 and 32 kDa are likely to carry T and B cell epitopes that could stimulate immune responses in a majority of individuals. The selected bands (144, 38 and 32 kDa) were found to include glycoproteins containing D-mannopyranosyl or glycosyl residues, and respectively 62.5, 46 and 55% amino acids by weight. The amino acid molar ratios of these bands were completely different.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Helminth,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Helminth Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0020-7519
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
113-21
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7541026-Adolescent,
pubmed-meshheading:7541026-Adult,
pubmed-meshheading:7541026-Animals,
pubmed-meshheading:7541026-Antigens, Helminth,
pubmed-meshheading:7541026-B-Lymphocytes,
pubmed-meshheading:7541026-Child,
pubmed-meshheading:7541026-Epitopes,
pubmed-meshheading:7541026-Female,
pubmed-meshheading:7541026-Glycoproteins,
pubmed-meshheading:7541026-Helminth Proteins,
pubmed-meshheading:7541026-Humans,
pubmed-meshheading:7541026-Immunity, Cellular,
pubmed-meshheading:7541026-Male,
pubmed-meshheading:7541026-Mice,
pubmed-meshheading:7541026-Molecular Weight,
pubmed-meshheading:7541026-Schistosoma mansoni,
pubmed-meshheading:7541026-Schistosomiasis haematobia,
pubmed-meshheading:7541026-Schistosomiasis mansoni,
pubmed-meshheading:7541026-Solubility,
pubmed-meshheading:7541026-T-Lymphocytes,
pubmed-meshheading:7541026-Vaccines
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Identification and characterization of Schistosoma mansoni antigens recognized by T and B lymphocytes of humans with early active intestinal and/or urinary schistosomiasis.
|
| pubmed:affiliation |
Zoology Department, Faculty of Science, Cairo University, Egypt.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
|