Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5-6
|
| pubmed:dateCreated |
1995-7-24
|
| pubmed:abstractText |
It has been previously demonstrated that the administration of recombinant human granulocyte-colony stimulating factor (rhG-CSF) ameliorates the decrease of the polymorphonuclear neutrophils (PMNs) count after the cytotoxic chemotherapies, thereby reducing the infection complications associated with neutropenia. In this multi-center study, we studied the prophylaxtic effect of rhG-CSF administration on infection complications in patients with non-Hodgkin malignant lymphoma, who received cytotoxic chemotherapies (CHOP or ProMACE/CytaBOM). rhG-CSF administration reduced the frequency of infection complications, and there was no obvious difference in it's frequency between the CHOP-treated and the ProMACE/CytaBOM-treated groups when administered with rhG-CSF, thereby indicating that third generation therapy for NHL may be safely completed in Japanese in combination with rhG-CSF administration. Furthermore, we investigated both the in vitro and the in vivo effects of rhG-CSF on the function of PMNs in patients with NHL and healthy donors, and revealed that the administration of rhG-CSF for NHL patients receiving cytotoxic chemotherapy brought on an improvement of the production of active oxygen but did not affect serum levels of IFNs, IL-1-beta, and IL-6, inspite of a slight elevation of TNF-alpha. Consistent with these results, in vitro treatment of PMNs with rhG-CSF induced no significant production of these inflammatory cytokines and their mRNA expressions. Furthermore, rhG-CSF administration showed no significant effects in vivo on the expression of CD11a, CD11b and LECAM-1 on PMNs and integrins on platelets.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bleomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclophosphamide,
http://linkedlifedata.com/resource/pubmed/chemical/Cytarabine,
http://linkedlifedata.com/resource/pubmed/chemical/Doxorubicin,
http://linkedlifedata.com/resource/pubmed/chemical/Etoposide,
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte Colony-Stimulating...,
http://linkedlifedata.com/resource/pubmed/chemical/Methotrexate,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Prednisone,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Vincristine
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1042-8194
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
471-6
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7540462-Adult,
pubmed-meshheading:7540462-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:7540462-Bleomycin,
pubmed-meshheading:7540462-Cell Adhesion Molecules,
pubmed-meshheading:7540462-Cyclophosphamide,
pubmed-meshheading:7540462-Cytarabine,
pubmed-meshheading:7540462-Doxorubicin,
pubmed-meshheading:7540462-Etoposide,
pubmed-meshheading:7540462-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:7540462-Humans,
pubmed-meshheading:7540462-Infection Control,
pubmed-meshheading:7540462-Luminescent Measurements,
pubmed-meshheading:7540462-Lymphoma, Non-Hodgkin,
pubmed-meshheading:7540462-Methotrexate,
pubmed-meshheading:7540462-Middle Aged,
pubmed-meshheading:7540462-Neoplasm Proteins,
pubmed-meshheading:7540462-Neutropenia,
pubmed-meshheading:7540462-Neutrophils,
pubmed-meshheading:7540462-Prednisone,
pubmed-meshheading:7540462-Recombinant Proteins,
pubmed-meshheading:7540462-Respiratory Burst,
pubmed-meshheading:7540462-Vincristine
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Effects of rhG-CSF on infection complications and impaired function of neutrophils secondary to chemotherapy for non-Hodgkin's lymphoma. Hokkaido Study Group of Malignant Lymphoma, and rhG-CSF, Japan.
|
| pubmed:affiliation |
Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
|
| pubmed:publicationType |
Journal Article,
Multicenter Study
|