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rdf:type |
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lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0007600,
umls-concept:C0023418,
umls-concept:C0033713,
umls-concept:C0086418,
umls-concept:C0994524,
umls-concept:C1333707,
umls-concept:C1514468,
umls-concept:C1519726,
umls-concept:C1527017,
umls-concept:C2346841
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pubmed:issue |
4
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pubmed:dateCreated |
1995-7-13
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pubmed:abstractText |
The vav proto-oncogene product (Vav) is expressed exclusively in hematopoietic cells and is reported to have guanine nucleotide exchange activity. Here we report that granulocyte-macrophage colony-stimulating factor, interleukin-3, and erythropoietin induce tyrosine phosphorylation of Vav in a human leukemia cell line UT-7. Tyrosine phosphorylation of Vav is rapid and transient; it occurs within 1 min of the stimulation and at physiological concentrations of the factors. Furthermore, we show that Vav is constitutively associated with the adapter molecule Grb2/Ash in UT-7. These data suggest that tyrosine kinases, the adapter Grb2/Ash, and the guanine nucleotide exchange factor Vav are members of a signaling pathway leading to Ras activation in hematopoietic cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Erythropoietin,
http://linkedlifedata.com/resource/pubmed/chemical/GRB2 Adaptor Protein,
http://linkedlifedata.com/resource/pubmed/chemical/GRB2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte-Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-3,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-vav,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins pp60(c-src),
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/VAV1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0910-5050
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
336-41
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7539782-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:7539782-Amino Acid Sequence,
pubmed-meshheading:7539782-Cell Cycle Proteins,
pubmed-meshheading:7539782-Erythropoietin,
pubmed-meshheading:7539782-GRB2 Adaptor Protein,
pubmed-meshheading:7539782-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:7539782-Humans,
pubmed-meshheading:7539782-Interleukin-3,
pubmed-meshheading:7539782-Leukemia,
pubmed-meshheading:7539782-Molecular Sequence Data,
pubmed-meshheading:7539782-Neoplasm Proteins,
pubmed-meshheading:7539782-Phosphorylation,
pubmed-meshheading:7539782-Protein-Tyrosine Kinases,
pubmed-meshheading:7539782-Proteins,
pubmed-meshheading:7539782-Proto-Oncogene Proteins,
pubmed-meshheading:7539782-Proto-Oncogene Proteins c-vav,
pubmed-meshheading:7539782-Proto-Oncogene Proteins pp60(c-src),
pubmed-meshheading:7539782-Receptor, Epidermal Growth Factor,
pubmed-meshheading:7539782-Signal Transduction,
pubmed-meshheading:7539782-Stimulation, Chemical,
pubmed-meshheading:7539782-Tumor Cells, Cultured,
pubmed-meshheading:7539782-ras Proteins
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pubmed:year |
1995
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pubmed:articleTitle |
Tyrosine phosphorylation of the proto-oncogene product Vav and its association with the adapter Grb2/Ash in a human leukemia cell line UT-7.
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pubmed:affiliation |
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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