Linked Life Data

753977

Source:http://linkedlifedata.com/resource/pubmed/id/753977

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
50
pubmed:dateCreated
1979-10-26
pubmed:abstractText
Previous observations and experiments have shown that the potent carcinogenic wavelengths for skin cancer in man are found in the 290- to 320-nm range, although shorter and longer wavelengths can also have an effect. The short wavelength limit (290 nm) is determined by thesolar emission reaching the earth's surface, a parameter that varies greatly with season, time, and atmopheric conditions. The long wavelength limit (320 nm) was based on observations of the effect of window glass filtration and on comparison of the effect of mid and long UV radiation. It provide little information as to the efficacy of wavelengths in this range. We performed a series of experiments to provide more specific comparative data by testing the hypothesis that the action spectrum for carcinogenesis parallel that for erythema. Albino mice were exposed the emission of a diffraction grating monochromator (5 nm half power bandwidth) at 290, 300, 310, and 320 nm. Energy levels were proportional to valves for the erythema spectrum of untanned Caucasian human skin. Exposures were given thrice weekly until 50% of the mice had developed tumors. Squamous cell carcinomas developed at approximately the same rate and frequency when the UV exposure was proportional to that for erythema, which indicated a decreasing potency from 300 to 310 to 320 nm. No tumors occurred in mice exposed to 290 nm.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0083-1921
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
27-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Action spectrum for ultraviolet carcinogenesis.
pubmed:publicationType
Journal Article