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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1995-6-29
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pubmed:abstractText |
The relationships between the integrin-mediated activation of inward rectifyier K+ channels (KIR), the phosphorylation of pp125FAK and the rescue of neuritogenesis were studied in 41A3 mouse neuroblastoma cells. Neuritogenesis, elicited by adhesion to FN-enriched substrata, was reversibly impaired by pretreating these cells with the tyrosine kinase inhibitor Herbimycin A. This impairment mimicked that operated by Cs+ ions, which selectively inhibited the integrin-mediated activation of KIR channels. Various phosphotyrosine containing cellular proteins underwent a marked increase upon cell adhesion to FN-coated dishes. This increase was significantly reduced by Cs+ addition. Immunoprecipitation of pp125FAK revealed that the phosphorylation of this kinase and several associated proteins was significantly and reversibly inhibited by Cs+, indicating that integrin-mediated activation of KIR channels is a limiting step upstream to the phosphorylation of pp125FAK in the commitment to neuritogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzoquinones,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Focal Adhesion Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Focal Adhesion Protein-Tyrosine...,
http://linkedlifedata.com/resource/pubmed/chemical/Lactams, Macrocyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Inwardly...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Ptk2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Quinones,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/herbimycin
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
210
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
823-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7539261-Animals,
pubmed-meshheading:7539261-Benzoquinones,
pubmed-meshheading:7539261-Cell Adhesion Molecules,
pubmed-meshheading:7539261-Cell Line,
pubmed-meshheading:7539261-Focal Adhesion Kinase 1,
pubmed-meshheading:7539261-Focal Adhesion Protein-Tyrosine Kinases,
pubmed-meshheading:7539261-Lactams, Macrocyclic,
pubmed-meshheading:7539261-Membrane Potentials,
pubmed-meshheading:7539261-Mice,
pubmed-meshheading:7539261-Neoplasm Proteins,
pubmed-meshheading:7539261-Neurites,
pubmed-meshheading:7539261-Neuroblastoma,
pubmed-meshheading:7539261-Patch-Clamp Techniques,
pubmed-meshheading:7539261-Phosphoproteins,
pubmed-meshheading:7539261-Phosphorylation,
pubmed-meshheading:7539261-Phosphotyrosine,
pubmed-meshheading:7539261-Potassium Channels,
pubmed-meshheading:7539261-Potassium Channels, Inwardly Rectifying,
pubmed-meshheading:7539261-Protein-Tyrosine Kinases,
pubmed-meshheading:7539261-Quinones,
pubmed-meshheading:7539261-Receptor, Insulin,
pubmed-meshheading:7539261-Tumor Cells, Cultured,
pubmed-meshheading:7539261-Tyrosine
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pubmed:year |
1995
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pubmed:articleTitle |
An inward rectifier K+ current modulates in neuroblastoma cells the tyrosine phosphorylation of the pp125FAK and associated proteins: role in neuritogenesis.
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pubmed:affiliation |
Institute of General Pathology, University of Florence, Firenze, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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