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rdf:type |
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lifeskim:mentions |
umls-concept:C0001792,
umls-concept:C0003250,
umls-concept:C0026809,
umls-concept:C0039194,
umls-concept:C0221102,
umls-concept:C0333668,
umls-concept:C0540218,
umls-concept:C0542560,
umls-concept:C1332714,
umls-concept:C1521828,
umls-concept:C1705241,
umls-concept:C1705242,
umls-concept:C2004454
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pubmed:issue |
12
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pubmed:dateCreated |
1995-6-29
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pubmed:abstractText |
We compared the degrees of depletion and the rates of recovery of CD4+ T cells in young and old mice given a single injection of an anti-CD4 (GK1.5) mAb. We found that in young mice the CD4+ population of T cells was completely depleted from the peripheral blood and, subsequently, the lymph nodes and spleen. Young mice recovered 80% of CD4+ T cells within 100 days after the injection. Although aged mice have less CD4+ T cells, CD4+ T cells were depleted by only 60% after mAb injection. This finding was associated with prolonged circulation of Ab-coated T cells. The rate of repopulation of peripheral CD4+ T cells was also affected by aging, because 5 times less CD4+ T cells appear in aged than in young mice between days 14 and 100 post injection. Further, we found that the CD4+ T cells that are depleted in both young and old mice by injection of anti-CD4 mAb are CD45RBhigh, suggesting a preferential depletion of immature cells. Finally, the thymus appears to be required to repopulate the T cell population post injection, because thymectomized young mice failed to recover CD3+CD4+ cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD44,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lymphocyte Homing
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
154
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6644-54
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7539027-Aging,
pubmed-meshheading:7539027-Animals,
pubmed-meshheading:7539027-Antibodies, Monoclonal,
pubmed-meshheading:7539027-Antigens, CD3,
pubmed-meshheading:7539027-Antigens, CD44,
pubmed-meshheading:7539027-Antigens, CD45,
pubmed-meshheading:7539027-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7539027-Carrier Proteins,
pubmed-meshheading:7539027-Cell Differentiation,
pubmed-meshheading:7539027-Lymphocyte Count,
pubmed-meshheading:7539027-Lymphocyte Depletion,
pubmed-meshheading:7539027-Lymphoid Tissue,
pubmed-meshheading:7539027-Mice,
pubmed-meshheading:7539027-Mice, Inbred BALB C,
pubmed-meshheading:7539027-Mice, Inbred C57BL,
pubmed-meshheading:7539027-Receptors, Cell Surface,
pubmed-meshheading:7539027-Receptors, Lymphocyte Homing,
pubmed-meshheading:7539027-Thymectomy,
pubmed-meshheading:7539027-Thymus Gland,
pubmed-meshheading:7539027-Time Factors
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pubmed:year |
1995
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pubmed:articleTitle |
Differences in the degree of depletion, rate of recovery, and the preferential elimination of naive CD4+ T cells by anti-CD4 monoclonal antibody (GK1.5) in young and aged mice.
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pubmed:affiliation |
Division of Nephrology, University of Texas Medical Branch, Galveston 77555, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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