Linked Life Data

7538700

Source:http://linkedlifedata.com/resource/pubmed/id/7538700

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-6-22
pubmed:abstractText
Understanding the role of ion channels in the generation of slow waves and action potentials in the myometrium is critical in designing strategies to regulate uterine contractile activity. The development of the patch clamp technique has allowed the identification of specific types of channels in the myometrium and provided insights into their regulation by hormones and drugs. Specifically, new studies suggest that KATP and KCa channel openers could be important tools in the management of inappropriate uterine contractions, but peripheral effects will have to be controlled. Conversely, blockers of these same channels may have some effects on dystocia. The study of contractant-operated channels in the myometrium is still in its infancy, but promises new insights into possible modes of regulation as well. Myometrial activity is controlled at a number of levels. The regulation of ion channels is an important aspect, but receptor-mediated actions that do not appear to be voltage- or ion-dependent presumably are also important contributors and hence are sites of potential modulation as well. Clearly, future multifaceted approaches to tocolysis, and perhaps also dystocia, may well include agents targeting the activity of ion channels.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0146-0005
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
31-40
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Ion channels and the control of myometrial electrical activity.
pubmed:affiliation
Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review