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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1995-6-8
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pubmed:abstractText |
An analogue of the C-terminal heptapeptide of cholecystokinin (CCK) t-Boc-Tyr(SO3-)-Nle-Gly-D-Trp-Nle-Asp-a-2-phenylethylester is a potent, specific CCK receptor antagonist. Intraperitoneal injection of the antagonist abolished suppression of real feeding and sham feeding by exogenous CCK-8 (1.8 nmol/kg), and significantly increased real feeding. Assuming an antagonist distribution like that of exogenous CCK-8, our results suggest that exogenous CCK-8 and endogenous CCK reduce food intake by acting at a site(s) accessible to peripherally administered peptides.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0195-6663
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7537951-Amino Acid Sequence,
pubmed-meshheading:7537951-Amylases,
pubmed-meshheading:7537951-Animals,
pubmed-meshheading:7537951-Eating,
pubmed-meshheading:7537951-Male,
pubmed-meshheading:7537951-Molecular Sequence Data,
pubmed-meshheading:7537951-Pancreas,
pubmed-meshheading:7537951-Peptide Fragments,
pubmed-meshheading:7537951-Rats,
pubmed-meshheading:7537951-Rats, Sprague-Dawley,
pubmed-meshheading:7537951-Receptors, Cholecystokinin,
pubmed-meshheading:7537951-Sincalide
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pubmed:year |
1995
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pubmed:articleTitle |
Peptide cholesystokinin receptor antagonist increases food intake in rats.
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pubmed:affiliation |
Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman 99164-6520, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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