Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-6-8
pubmed:abstractText
1. Oedema formation induced by intradermal capsaicin has been studied in rabbit skin. The effect of the anti-inflammatory steroid dexamethasone and also of a range of known inhibitors of oedema formation have been investigated in order to elucidate mechanisms involved in capsaicin-induced oedema formation. 2. Oedema formation, in response to intradermally-injected test agents, was measured by the local extravascular accumulation of intravenously injected 125I-labelled albumin. In separate experiments skin blood flow was assessed by the clearance of intradermally-injected 133xenon. 3. Oedema formation induced by intradermal histamine (3 nmol) and bradykinin (1 nmol), when in the presence of vasodilator doses of calcitonin gene-related peptide (CGRP) (3 pmol) or prostaglandin E1, (PGE1) (10 pmol), was significantly inhibited (P < 0.01) in rabbits pretreated with intravenous dexamethasone (3 mg kg-1, -4 h). In contrast dexamethasone had no effect on capsaicin (3 mumol)-induced oedema formation or, on capsaicin (30-100 nmol)-induced blood flow. 4. Oedema formation observed in response to intradermal capsaicin (3 mumol) was significantly inhibited (P < 0.01) when the selective capsaicin antagonist, ruthenium red (3 nmol) was co-injected. This suggests that the mechanism of capsaicin-induced oedema involves activation of sensory nerves. However, oedema was not inhibited when capsaicin was co-injected with the neurokinin NK1 receptor antagonist, RP67580 (10 nmol), the NK2 antagonist SR48960 (10 nmol) or the CGRP antagonist CGRP8-37 (300 pmol). 5. Oedema formation induced by capsaicin was not inhibited when co-injected with the histamine HI receptor antagonist, mepyramine (3 nmol), the PAF antagonist, WEB 2086 (100 nmol), the bradykinin B2 receptor antagonist, Hoel4O (1 nmol), or the cyclo-oxygenase inhibitor, indomethacin (10 nmol),suggesting that these mediators do not play a major role in the capsaicin-induced response.6. Histological analysis of capsaicin-treated skin sites revealed undamaged, intact microvessels and lack of haemorrhage. Further, co-injection of capsaicin with the hydrogen peroxide remover, catalase(2,200 u), had no effect on oedema formation. This suggests that capsaicin does not induce oedema formation secondary to free radical-induced damage.7. These results indicate that capsaicin-induced oedema in rabbit skin involves activation of sensory nerves. However, the oedema is not inhibited by pretreatment with the anti-inflammatory steroid,dexamethasone. Further the mechanisms which lead to the oedema formation observed after intradermal capsaicin remain unknown.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-1249742, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-1281720, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-1371190, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-1371395, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-1377627, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-1377821, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-1425974, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-1456180, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-1504745, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-1691945, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-1714841, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-1717108, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-1719549, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-1724624, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-1786800, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-1797334, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-2416378, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-2452458, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-2457810, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-2470103, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-2580420, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-2580718, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-3683864, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-371730, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-4271544, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-6893620, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-7510080, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-7523980, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-7682180, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-7684305, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-7686493, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-8004386, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-8032633, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-8317312, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-8317318, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-8387386, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-8448601, http://linkedlifedata.com/resource/pubmed/commentcorrection/7537589-8485631
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Alprostadil, http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents..., http://linkedlifedata.com/resource/pubmed/chemical/Benzamides, http://linkedlifedata.com/resource/pubmed/chemical/Bradykinin, http://linkedlifedata.com/resource/pubmed/chemical/Calcitonin Gene-Related Peptide, http://linkedlifedata.com/resource/pubmed/chemical/Capsaicin, http://linkedlifedata.com/resource/pubmed/chemical/Catalase, http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone, http://linkedlifedata.com/resource/pubmed/chemical/Histamine, http://linkedlifedata.com/resource/pubmed/chemical/Indoles, http://linkedlifedata.com/resource/pubmed/chemical/Indomethacin, http://linkedlifedata.com/resource/pubmed/chemical/Isoindoles, http://linkedlifedata.com/resource/pubmed/chemical/Piperidines, http://linkedlifedata.com/resource/pubmed/chemical/RP 67580, http://linkedlifedata.com/resource/pubmed/chemical/Ruthenium Red, http://linkedlifedata.com/resource/pubmed/chemical/SR 48968, http://linkedlifedata.com/resource/pubmed/chemical/Substance P, http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
114
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
570-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:7537589-Animals, pubmed-meshheading:7537589-Injections, Intravenous, pubmed-meshheading:7537589-Skin, pubmed-meshheading:7537589-Histamine, pubmed-meshheading:7537589-Edema, pubmed-meshheading:7537589-Piperidines, pubmed-meshheading:7537589-Catalase, pubmed-meshheading:7537589-Rabbits, pubmed-meshheading:7537589-Indoles, pubmed-meshheading:7537589-Male, pubmed-meshheading:7537589-Capsaicin, pubmed-meshheading:7537589-Vasodilator Agents, pubmed-meshheading:7537589-Capillary Permeability, pubmed-meshheading:7537589-Benzamides, pubmed-meshheading:7537589-Dexamethasone, pubmed-meshheading:7537589-Bradykinin, pubmed-meshheading:7537589-Regional Blood Flow, pubmed-meshheading:7537589-Injections, Intradermal, pubmed-meshheading:7537589-Substance P, pubmed-meshheading:7537589-Indomethacin, pubmed-meshheading:7537589-Anti-Inflammatory Agents, Non-Steroidal, pubmed-meshheading:7537589-Drug Interactions
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