Linked Life Data

7537557

Source:http://linkedlifedata.com/resource/pubmed/id/7537557

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:7537557rdf:typepubmed:Citationlld:pubmed
pubmed-article:7537557lifeskim:mentionsumls-concept:C0242629lld:lifeskim
pubmed-article:7537557lifeskim:mentionsumls-concept:C0018133lld:lifeskim
pubmed-article:7537557lifeskim:mentionsumls-concept:C1332714lld:lifeskim
pubmed-article:7537557lifeskim:mentionsumls-concept:C1420364lld:lifeskim
pubmed-article:7537557lifeskim:mentionsumls-concept:C0443199lld:lifeskim
pubmed-article:7537557lifeskim:mentionsumls-concept:C0851285lld:lifeskim
pubmed-article:7537557pubmed:issue6lld:pubmed
pubmed-article:7537557pubmed:dateCreated1995-6-8lld:pubmed
pubmed-article:7537557pubmed:abstractTextTwo distinct T-cell glycoforms of CD43 result from differential glycosylation of a single gene product in vivo. The 115 kDa glycoform carries mainly tetrasaccharides and is a pan T-cell marker, whereas the 130 kDa glycoform carries mainly hexasaccharides and is associated with T-cell activation. CD43 has been shown to play a role both in enhancing and inhibiting cell adhesion; however, the function of the individual glycoforms is unknown. We have examined the distribution and regulation of the CD43 glycoforms in a murine model of acute graft-versus-host disease (GVHD) using monoclonal antibodies (mAbs) S7 and 1B11 specific for the 115 and 130 kDa CD43 glycoforms, respectively. An increase in T-lymphocyte CD43 130 kDa expression occurred during GVHD from day 4 onwards and coincided with splenomegaly and upregulation of the beta 1-6GlcNAc transferase (C2GnT), the key enzyme responsible for the addition of complex O-glycan branching to CD43. When T-lymphocyte subsets were examined for CD43 expression, we found that in GVHD, both CD43 glycoforms were upregulated on CD4+ T cells. However, in CD8+ T cells, CD43 115 kDa was downregulated while CD43 130 kDa was dramatically upregulated, such that two distinct CD8+1B11+ T-cell subsets were observed. These data demonstrate differential expression of the CD43 glycoforms in both resting and activated CD4+ and CD8+ T cells, and suggest that glycosylation differences between the CD43 glycoforms may reflect participation in the different functions of these T-cell subsets in immune disorders in vivo.lld:pubmed
pubmed-article:7537557pubmed:languageenglld:pubmed
pubmed-article:7537557pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7537557pubmed:citationSubsetIMlld:pubmed
pubmed-article:7537557pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7537557pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7537557pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7537557pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7537557pubmed:statusMEDLINElld:pubmed
pubmed-article:7537557pubmed:monthDeclld:pubmed
pubmed-article:7537557pubmed:issn0959-6658lld:pubmed
pubmed-article:7537557pubmed:authorpubmed-author:WilliamsM JMJlld:pubmed
pubmed-article:7537557pubmed:authorpubmed-author:JonesA TATlld:pubmed
pubmed-article:7537557pubmed:authorpubmed-author:ElliesL GLGlld:pubmed
pubmed-article:7537557pubmed:authorpubmed-author:ZiltenerH JHJlld:pubmed
pubmed-article:7537557pubmed:issnTypePrintlld:pubmed
pubmed-article:7537557pubmed:volume4lld:pubmed
pubmed-article:7537557pubmed:ownerNLMlld:pubmed
pubmed-article:7537557pubmed:authorsCompleteYlld:pubmed
pubmed-article:7537557pubmed:pagination885-93lld:pubmed
pubmed-article:7537557pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:7537557pubmed:meshHeadingpubmed-meshheading:7537557-...lld:pubmed
pubmed-article:7537557pubmed:meshHeadingpubmed-meshheading:7537557-...lld:pubmed
pubmed-article:7537557pubmed:meshHeadingpubmed-meshheading:7537557-...lld:pubmed
pubmed-article:7537557pubmed:meshHeadingpubmed-meshheading:7537557-...lld:pubmed
pubmed-article:7537557pubmed:meshHeadingpubmed-meshheading:7537557-...lld:pubmed
pubmed-article:7537557pubmed:meshHeadingpubmed-meshheading:7537557-...lld:pubmed
pubmed-article:7537557pubmed:meshHeadingpubmed-meshheading:7537557-...lld:pubmed
pubmed-article:7537557pubmed:meshHeadingpubmed-meshheading:7537557-...lld:pubmed
pubmed-article:7537557pubmed:meshHeadingpubmed-meshheading:7537557-...lld:pubmed
pubmed-article:7537557pubmed:meshHeadingpubmed-meshheading:7537557-...lld:pubmed
pubmed-article:7537557pubmed:meshHeadingpubmed-meshheading:7537557-...lld:pubmed
pubmed-article:7537557pubmed:meshHeadingpubmed-meshheading:7537557-...lld:pubmed
pubmed-article:7537557pubmed:meshHeadingpubmed-meshheading:7537557-...lld:pubmed
pubmed-article:7537557pubmed:meshHeadingpubmed-meshheading:7537557-...lld:pubmed
pubmed-article:7537557pubmed:meshHeadingpubmed-meshheading:7537557-...lld:pubmed
pubmed-article:7537557pubmed:meshHeadingpubmed-meshheading:7537557-...lld:pubmed
pubmed-article:7537557pubmed:meshHeadingpubmed-meshheading:7537557-...lld:pubmed
pubmed-article:7537557pubmed:meshHeadingpubmed-meshheading:7537557-...lld:pubmed
pubmed-article:7537557pubmed:meshHeadingpubmed-meshheading:7537557-...lld:pubmed
pubmed-article:7537557pubmed:meshHeadingpubmed-meshheading:7537557-...lld:pubmed
pubmed-article:7537557pubmed:meshHeadingpubmed-meshheading:7537557-...lld:pubmed
pubmed-article:7537557pubmed:year1994lld:pubmed
pubmed-article:7537557pubmed:articleTitleDifferential regulation of CD43 glycoforms on CD4+ and CD8+ T lymphocytes in graft-versus-host disease.lld:pubmed
pubmed-article:7537557pubmed:affiliationBiomedical Research Centre, University of British Columbia, Vancouver, Canada.lld:pubmed
pubmed-article:7537557pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:7537557pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7537557lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7537557lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7537557lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7537557lld:pubmed