Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1995-5-30
|
| pubmed:abstractText |
We have used conventional whole-cell electrophysiological recording techniques to measure the level of expression of tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium currents in the capsaicin-sensitive and capsaicin-insensitive subpopulations of dorsal root ganglion neurons. We find that there are significantly higher levels of TTX-R expressed in the capsaicin-sensitive group but no difference in the levels of TTX-S. Since capsaicin is a selective stimulant of polymodal nociceptors, these data raise the possibility that TTX-R sodium channels may be an important determinant of nociceptor phenotype.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0304-3940
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
6
|
| pubmed:volume |
185
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
70-3
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7537359-Animals,
pubmed-meshheading:7537359-Capsaicin,
pubmed-meshheading:7537359-Ganglia, Spinal,
pubmed-meshheading:7537359-Gene Expression,
pubmed-meshheading:7537359-Ion Channels,
pubmed-meshheading:7537359-Patch-Clamp Techniques,
pubmed-meshheading:7537359-Phenotype,
pubmed-meshheading:7537359-Rats,
pubmed-meshheading:7537359-Sodium Channels,
pubmed-meshheading:7537359-Tetrodotoxin
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Expression of tetrodotoxin-resistant sodium channels in capsaicin-sensitive dorsal root ganglion neurons of adult rats.
|
| pubmed:affiliation |
Sandoz Institute for Medical Research, London, UK.
|
| pubmed:publicationType |
Journal Article
|