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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1995-5-25
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pubmed:abstractText |
During early mammalian embryogenesis, one of the two X chromosomes in somatic cells of the female becomes inactivated through a process that is thought to depend on a unique initiator region, the X-chromosome inactivation center (Xic). The recently characterized Xist sequence (X-inactive-specific transcript) is thought to be a possible candidate for Xic. In mice a further genetic element, the X chromosome-controlling element (Xce), is also known to influence the choice of which of the two X chromosomes is inactivated. We report that a region of the mouse X chromosome lying 15 kb distal to Xist contains several sites that show hypermethylation specifically associated with the active X chromosome. Analysis of this region in various Xce strains has revealed a correlation between the strength of the Xce allele carried and the methylation status of this region. We propose that such a region could be involved in the initial stages of the inactivation process and in particular in the choice of which of the two X chromosomes present in a female cell will be inactivated.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7536936-1369742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7536936-1423610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7536936-14248461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7536936-1961248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7536936-1985261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7536936-2034278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7536936-2034279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7536936-2055107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7536936-3790119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7536936-5075805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7536936-5480753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7536936-7262551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7536936-7726900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7536936-7864936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7536936-8118102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7536936-8156596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7536936-8364571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7536936-8425217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7536936-8468050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7536936-8516846
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Restriction-Modification Enzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyribonuclease HpaII,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyribonucleases, Type II...,
http://linkedlifedata.com/resource/pubmed/chemical/GTCGAC-specific type II...,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoglycerate Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Untranslated,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/X (inactive)-specific transcript...
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
92
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pubmed:geneSymbol |
Xist
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3531-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7536936-Animals,
pubmed-meshheading:7536936-DNA,
pubmed-meshheading:7536936-DNA Restriction-Modification Enzymes,
pubmed-meshheading:7536936-Deoxyribonuclease HpaII,
pubmed-meshheading:7536936-Deoxyribonucleases, Type II Site-Specific,
pubmed-meshheading:7536936-Dosage Compensation, Genetic,
pubmed-meshheading:7536936-Female,
pubmed-meshheading:7536936-Genetic Variation,
pubmed-meshheading:7536936-Haplotypes,
pubmed-meshheading:7536936-Male,
pubmed-meshheading:7536936-Methylation,
pubmed-meshheading:7536936-Mice,
pubmed-meshheading:7536936-Mice, Inbred Strains,
pubmed-meshheading:7536936-Phosphoglycerate Kinase,
pubmed-meshheading:7536936-RNA, Untranslated,
pubmed-meshheading:7536936-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:7536936-Restriction Mapping,
pubmed-meshheading:7536936-Sex Differentiation,
pubmed-meshheading:7536936-Species Specificity,
pubmed-meshheading:7536936-Transcription Factors,
pubmed-meshheading:7536936-X Chromosome
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pubmed:year |
1995
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pubmed:articleTitle |
Xce haplotypes show modified methylation in a region of the active X chromosome lying 3' to Xist.
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pubmed:affiliation |
Unité de Génétique Moléculaire Murine, Institut Pasteur, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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