pubmed-article:7536102 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:7536102 | lifeskim:mentions | umls-concept:C0031330 | lld:lifeskim |
pubmed-article:7536102 | lifeskim:mentions | umls-concept:C0008046 | lld:lifeskim |
pubmed-article:7536102 | lifeskim:mentions | umls-concept:C1383501 | lld:lifeskim |
pubmed-article:7536102 | lifeskim:mentions | umls-concept:C0086045 | lld:lifeskim |
pubmed-article:7536102 | lifeskim:mentions | umls-concept:C2333402 | lld:lifeskim |
pubmed-article:7536102 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
pubmed-article:7536102 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
pubmed-article:7536102 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:7536102 | pubmed:dateCreated | 1995-5-12 | lld:pubmed |
pubmed-article:7536102 | pubmed:abstractText | Chick embryo ciliary ganglion cells were acutely isolated, and the mechanism(s) underlying the increase in the cytosolic Ca2+ concentration ([Ca]in) induced by high concentrations of nicotine examined using fura-2 microfluorometry. The order of potencies of nicotinic receptor agonists in increasing [Ca]in was ACh > nicotine = dimethylphenylpiperazinium > cytisine. The nicotine-induced increase in [Ca]in was inhibited not only by nicotinic antagonists but also by muscarinic antagonists, while the muscarine-induced [Ca]in increase was little affected by nicotinic antagonists. The nicotine-induced [Ca]in increase was inhibited by both L- and N-type Ca2+ channel blockers and potentiated by an L-type Ca2+ channel agonist, Bay-K-8644. Nicotine also increased the cytosolic Na+ concentration ([Na]in) as measured by sodium binding benzofuranisophthalate microfluorometry, and this [Na]in increase was inhibited by various agents which reportedly affected nicotinic receptor channels in adrenal chromaffin cells. These results suggest that nicotine increased Na+ influx through nicotinic receptor channels resulting in membrane depolarization, which in turn increased Ca2+ influx through voltage-dependent Ca2+ channels. However, nicotine still increased influxes of Ca2+ and Mn2+ in the absence of external Na+, suggesting that nicotinic receptor channels in these cells are permeable not only to monovalent cations but also to Ca2+ and Mn2+. | lld:pubmed |
pubmed-article:7536102 | pubmed:language | eng | lld:pubmed |
pubmed-article:7536102 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7536102 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:7536102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7536102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7536102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7536102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7536102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7536102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7536102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7536102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7536102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7536102 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:7536102 | pubmed:month | Jan | lld:pubmed |
pubmed-article:7536102 | pubmed:issn | 0006-8993 | lld:pubmed |
pubmed-article:7536102 | pubmed:author | pubmed-author:SorimachiMM | lld:pubmed |
pubmed-article:7536102 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:7536102 | pubmed:day | 9 | lld:pubmed |
pubmed-article:7536102 | pubmed:volume | 669 | lld:pubmed |
pubmed-article:7536102 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:7536102 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:7536102 | pubmed:pagination | 26-34 | lld:pubmed |
pubmed-article:7536102 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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pubmed-article:7536102 | pubmed:year | 1995 | lld:pubmed |
pubmed-article:7536102 | pubmed:articleTitle | Pharmacology of nicotine-induced increase in cytosolic Ca2+ concentrations in chick embryo ciliary ganglion cells. | lld:pubmed |
pubmed-article:7536102 | pubmed:affiliation | Department of Physiology, Kagoshima University School of Medicine, Japan. | lld:pubmed |
pubmed-article:7536102 | pubmed:publicationType | Journal Article | lld:pubmed |