Linked Life Data

7536102

Source:http://linkedlifedata.com/resource/pubmed/id/7536102

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-5-12
pubmed:abstractText
Chick embryo ciliary ganglion cells were acutely isolated, and the mechanism(s) underlying the increase in the cytosolic Ca2+ concentration ([Ca]in) induced by high concentrations of nicotine examined using fura-2 microfluorometry. The order of potencies of nicotinic receptor agonists in increasing [Ca]in was ACh > nicotine = dimethylphenylpiperazinium > cytisine. The nicotine-induced increase in [Ca]in was inhibited not only by nicotinic antagonists but also by muscarinic antagonists, while the muscarine-induced [Ca]in increase was little affected by nicotinic antagonists. The nicotine-induced [Ca]in increase was inhibited by both L- and N-type Ca2+ channel blockers and potentiated by an L-type Ca2+ channel agonist, Bay-K-8644. Nicotine also increased the cytosolic Na+ concentration ([Na]in) as measured by sodium binding benzofuranisophthalate microfluorometry, and this [Na]in increase was inhibited by various agents which reportedly affected nicotinic receptor channels in adrenal chromaffin cells. These results suggest that nicotine increased Na+ influx through nicotinic receptor channels resulting in membrane depolarization, which in turn increased Ca2+ influx through voltage-dependent Ca2+ channels. However, nicotine still increased influxes of Ca2+ and Mn2+ in the absence of external Na+, suggesting that nicotinic receptor channels in these cells are permeable not only to monovalent cations but also to Ca2+ and Mn2+.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
669
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
26-34
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Pharmacology of nicotine-induced increase in cytosolic Ca2+ concentrations in chick embryo ciliary ganglion cells.
pubmed:affiliation
Department of Physiology, Kagoshima University School of Medicine, Japan.
pubmed:publicationType
Journal Article