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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1995-5-5
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pubmed:abstractText |
We have studied the reactive responses of both astrocytes and microglia to dopaminergic denervation of the striatum by MPTP. Following MPTP treatment, increased GFAP immunoreactivity reached a peak at 2 days and persisted for at least 6 weeks. Immunoreactivity to vimentin was also markedly increased in astrocytes 48 h after MPTP treatment. Striatal laminin immunoreactivity, however, appeared to be unaffected by drug treatment. GFAP protein levels increased to 196% and 321% of control 24 and 48 hours after MPTP treatment, respectively. Concomitantly, GFAP mRNA levels increased to 560% and 1620% of control, respectively. These reactive changes in striatal astrocytes in response to MPTP treatment were also accompanied by a reactive microglial response as evidenced by increased immunohistochemical visualization of striatal microglia using antibodies to Mac-1. Our results and those reported previously by O'Callaghan et al., strongly suggest that MPTP-induced reactive gliosis in mouse striatum is associated with reactive microglia, albeit without increased interleukin-1 beta.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0892-0362
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7-12
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pubmed:dateRevised |
2009-10-26
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pubmed:meshHeading |
pubmed-meshheading:7535890-Animals,
pubmed-meshheading:7535890-Antigens, Surface,
pubmed-meshheading:7535890-Astrocytes,
pubmed-meshheading:7535890-Blotting, Northern,
pubmed-meshheading:7535890-Blotting, Western,
pubmed-meshheading:7535890-Glial Fibrillary Acidic Protein,
pubmed-meshheading:7535890-Immunohistochemistry,
pubmed-meshheading:7535890-Laminin,
pubmed-meshheading:7535890-MPTP Poisoning,
pubmed-meshheading:7535890-Male,
pubmed-meshheading:7535890-Mice,
pubmed-meshheading:7535890-Mice, Inbred C57BL,
pubmed-meshheading:7535890-Neostriatum,
pubmed-meshheading:7535890-Nerve Tissue Proteins,
pubmed-meshheading:7535890-Neuroglia,
pubmed-meshheading:7535890-RNA,
pubmed-meshheading:7535890-Tyrosine 3-Monooxygenase,
pubmed-meshheading:7535890-Vimentin
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pubmed:articleTitle |
Neuroglial responses to the dopaminergic neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mouse striatum.
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pubmed:affiliation |
Department of Anatomy, University of Maryland School of Medicine, Baltimore 21201.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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