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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1995-5-10
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pubmed:abstractText |
To determine the extent which Ca dependent K current (IKCa) contributes during an action potential (AP), bovine chromaffin cells were voltage-clamped using a pre-recorded AP as the command voltage waveform. Based on (1) differential sensitivity of IKCa and Ca-independent K current (IK) to tetraethylammonium; (2) measurements of AP currents under conditions where Ca activation of IKCa had been abolished; and (3) blockade by charybdotoxin, IKCa comprised 70-90% of the outward K current during AP repolarization. In addition, observations are made concerning the form of AP-evoked Ca current.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
668
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
246-51
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7535656-Action Potentials,
pubmed-meshheading:7535656-Adrenal Medulla,
pubmed-meshheading:7535656-Animals,
pubmed-meshheading:7535656-Calcium,
pubmed-meshheading:7535656-Cattle,
pubmed-meshheading:7535656-Cell Line,
pubmed-meshheading:7535656-Charybdotoxin,
pubmed-meshheading:7535656-Patch-Clamp Techniques,
pubmed-meshheading:7535656-Potassium Channels,
pubmed-meshheading:7535656-Scorpion Venoms,
pubmed-meshheading:7535656-Tetraethylammonium Compounds,
pubmed-meshheading:7535656-Tetrodotoxin
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pubmed:year |
1994
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pubmed:articleTitle |
A major role for calcium-dependent potassium current in action potential repolarization in adrenal chromaffin cells.
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pubmed:affiliation |
Department of Anesthesiology, University of Virginia Health Sciences Center, Charlottesville 22908, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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