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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1995-5-9
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pubmed:abstractText |
In a search for new inhibitors of RNA-directed DNA-polymerases kuehneromycin A (1) was isolated from fermentations of a Tasmanian Kuehneromyces species. Its structure was elucidated by spectroscopic methods. Kuehneromycin A (1) is a non-competitive inhibitor of avian myeloblastosis virus (Ki 200 microM) and moloney murine leukemia virus (Ki 40 microM) reverse transcriptases. The second compound, kuehneromycin B (2) is a strong inhibitor of platelet aggregation stimulated with different inducers. In addition, both compounds exhibit cytotoxic and antimicrobial activities.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0939-5075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-9
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pubmed:dateRevised |
2009-11-4
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pubmed:meshHeading |
pubmed-meshheading:7535532-3T3 Cells,
pubmed-meshheading:7535532-Aldehydes,
pubmed-meshheading:7535532-Animals,
pubmed-meshheading:7535532-Anti-Bacterial Agents,
pubmed-meshheading:7535532-Avian myeloblastosis virus,
pubmed-meshheading:7535532-Bacteria,
pubmed-meshheading:7535532-Basidiomycota,
pubmed-meshheading:7535532-Benzofurans,
pubmed-meshheading:7535532-Carcinoma, Ehrlich Tumor,
pubmed-meshheading:7535532-Cell Survival,
pubmed-meshheading:7535532-Fermentation,
pubmed-meshheading:7535532-Fungi,
pubmed-meshheading:7535532-HIV Reverse Transcriptase,
pubmed-meshheading:7535532-HIV-1,
pubmed-meshheading:7535532-Kinetics,
pubmed-meshheading:7535532-Leukemia L1210,
pubmed-meshheading:7535532-Mice,
pubmed-meshheading:7535532-Microbial Sensitivity Tests,
pubmed-meshheading:7535532-Molecular Structure,
pubmed-meshheading:7535532-Moloney murine sarcoma virus,
pubmed-meshheading:7535532-Platelet Aggregation Inhibitors,
pubmed-meshheading:7535532-Reverse Transcriptase Inhibitors,
pubmed-meshheading:7535532-Tasmania,
pubmed-meshheading:7535532-Tetrahydronaphthalenes,
pubmed-meshheading:7535532-Tumor Cells, Cultured
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pubmed:articleTitle |
Kuehneromycins A and B, two new biological active compounds from a Tasmanian Kuehneromyces sp. (Strophariaceae, Basidiomycetes).
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pubmed:affiliation |
Lehrbereich Biotechnologie der Universität, Bundesrepublik, Deutschland.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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