Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-5-4
pubmed:abstractText
GABAergic modulation of enkephalin, substance P and glutamic acid decarboxylase (GAD67) gene expression and the alterations induced by dopamine receptor blockade were studied in the rat striatum. Following subchronic treatment with the GABA-A agonist muscimol, the GABA-B agonist baclofen or the GABA transaminase inhibitor gamma-vinyl GABA there were no significant changes in striatal peptide and GAD67 gene expression. Following repeated administration of the D-2 antagonists, eticlopride and haloperidol, there was an increase in enkephalin and GAD67 mRNA levels and parallel decrease in that of substance P. These were unaffected by co-administration of gamma-vinyl GABA. The D-1 antagonist, SCH 23390 administered alone or together with gamma-vinyl GABA did not alter peptide or GAD67 mRNA levels. It seems that pharmacological stimulation of GABA receptors has little effect on enkephalin, substance P or GAD67 mRNA expression in striatal output neurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Baclofen, http://linkedlifedata.com/resource/pubmed/chemical/Benzazepines, http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/Enkephalins, http://linkedlifedata.com/resource/pubmed/chemical/Glutamate Decarboxylase, http://linkedlifedata.com/resource/pubmed/chemical/Haloperidol, http://linkedlifedata.com/resource/pubmed/chemical/Muscimol, http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, GABA, http://linkedlifedata.com/resource/pubmed/chemical/Salicylamides, http://linkedlifedata.com/resource/pubmed/chemical/Substance P, http://linkedlifedata.com/resource/pubmed/chemical/Tachykinins, http://linkedlifedata.com/resource/pubmed/chemical/Vigabatrin, http://linkedlifedata.com/resource/pubmed/chemical/eticlopride, http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid, http://linkedlifedata.com/resource/pubmed/chemical/preproenkephalin, http://linkedlifedata.com/resource/pubmed/chemical/preprotachykinin
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
180
pubmed:geneSymbol
GAD67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
273-6
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:7535410-Animals, pubmed-meshheading:7535410-Baclofen, pubmed-meshheading:7535410-Benzazepines, pubmed-meshheading:7535410-Corpus Striatum, pubmed-meshheading:7535410-Dopamine Antagonists, pubmed-meshheading:7535410-Enkephalins, pubmed-meshheading:7535410-Gene Expression Regulation, pubmed-meshheading:7535410-Glutamate Decarboxylase, pubmed-meshheading:7535410-Haloperidol, pubmed-meshheading:7535410-In Situ Hybridization, pubmed-meshheading:7535410-Male, pubmed-meshheading:7535410-Muscimol, pubmed-meshheading:7535410-Protein Precursors, pubmed-meshheading:7535410-RNA, Messenger, pubmed-meshheading:7535410-Rats, pubmed-meshheading:7535410-Rats, Wistar, pubmed-meshheading:7535410-Receptors, Dopamine D2, pubmed-meshheading:7535410-Receptors, GABA, pubmed-meshheading:7535410-Salicylamides, pubmed-meshheading:7535410-Substance P, pubmed-meshheading:7535410-Tachykinins, pubmed-meshheading:7535410-Vigabatrin, pubmed-meshheading:7535410-gamma-Aminobutyric Acid
pubmed:year
1994
pubmed:articleTitle
GABAergic modulation of striatal peptide expression in rats and the alterations induced by dopamine antagonist treatment.
pubmed:affiliation
Neurodegenerative Diseases Research Centre, King's College, London, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't