rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-5-4
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pubmed:abstractText |
GABAergic modulation of enkephalin, substance P and glutamic acid decarboxylase (GAD67) gene expression and the alterations induced by dopamine receptor blockade were studied in the rat striatum. Following subchronic treatment with the GABA-A agonist muscimol, the GABA-B agonist baclofen or the GABA transaminase inhibitor gamma-vinyl GABA there were no significant changes in striatal peptide and GAD67 gene expression. Following repeated administration of the D-2 antagonists, eticlopride and haloperidol, there was an increase in enkephalin and GAD67 mRNA levels and parallel decrease in that of substance P. These were unaffected by co-administration of gamma-vinyl GABA. The D-1 antagonist, SCH 23390 administered alone or together with gamma-vinyl GABA did not alter peptide or GAD67 mRNA levels. It seems that pharmacological stimulation of GABA receptors has little effect on enkephalin, substance P or GAD67 mRNA expression in striatal output neurons.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Baclofen,
http://linkedlifedata.com/resource/pubmed/chemical/Benzazepines,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalins,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamate Decarboxylase,
http://linkedlifedata.com/resource/pubmed/chemical/Haloperidol,
http://linkedlifedata.com/resource/pubmed/chemical/Muscimol,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, GABA,
http://linkedlifedata.com/resource/pubmed/chemical/Salicylamides,
http://linkedlifedata.com/resource/pubmed/chemical/Substance P,
http://linkedlifedata.com/resource/pubmed/chemical/Tachykinins,
http://linkedlifedata.com/resource/pubmed/chemical/Vigabatrin,
http://linkedlifedata.com/resource/pubmed/chemical/eticlopride,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/preproenkephalin,
http://linkedlifedata.com/resource/pubmed/chemical/preprotachykinin
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
180
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pubmed:geneSymbol |
GAD67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
273-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7535410-Animals,
pubmed-meshheading:7535410-Baclofen,
pubmed-meshheading:7535410-Benzazepines,
pubmed-meshheading:7535410-Corpus Striatum,
pubmed-meshheading:7535410-Dopamine Antagonists,
pubmed-meshheading:7535410-Enkephalins,
pubmed-meshheading:7535410-Gene Expression Regulation,
pubmed-meshheading:7535410-Glutamate Decarboxylase,
pubmed-meshheading:7535410-Haloperidol,
pubmed-meshheading:7535410-In Situ Hybridization,
pubmed-meshheading:7535410-Male,
pubmed-meshheading:7535410-Muscimol,
pubmed-meshheading:7535410-Protein Precursors,
pubmed-meshheading:7535410-RNA, Messenger,
pubmed-meshheading:7535410-Rats,
pubmed-meshheading:7535410-Rats, Wistar,
pubmed-meshheading:7535410-Receptors, Dopamine D2,
pubmed-meshheading:7535410-Receptors, GABA,
pubmed-meshheading:7535410-Salicylamides,
pubmed-meshheading:7535410-Substance P,
pubmed-meshheading:7535410-Tachykinins,
pubmed-meshheading:7535410-Vigabatrin,
pubmed-meshheading:7535410-gamma-Aminobutyric Acid
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pubmed:year |
1994
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pubmed:articleTitle |
GABAergic modulation of striatal peptide expression in rats and the alterations induced by dopamine antagonist treatment.
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pubmed:affiliation |
Neurodegenerative Diseases Research Centre, King's College, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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