| pubmed-article:7534700 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7534700 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:7534700 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:7534700 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:7534700 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:7534700 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:7534700 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:7534700 | lifeskim:mentions | umls-concept:C0348080 | lld:lifeskim |
| pubmed-article:7534700 | lifeskim:mentions | umls-concept:C1448132 | lld:lifeskim |
| pubmed-article:7534700 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7534700 | pubmed:dateCreated | 1995-4-25 | lld:pubmed |
| pubmed-article:7534700 | pubmed:abstractText | The effects of insulin to stimulate metabolic and mitogenic responses were examined in Rat 1 fibroblast cells that overexpressed either normal (HIRc) or kinase-deficient human insulin receptors. When studied at the optimal growth stage for each cell line, insulin-stimulated responses measured in cells containing kinase-defective receptors with a Lys1018-Ala1018 substitution in the ATP-binding site of the kinase domain (A/K1018). Maximal insulin responsiveness for all these effects, measured as fold-increase over basal, was comparable in parental and HIRc cells (1.8- to 2.4-fold increases). Relative insulin responsiveness for all effects was greatest in A/K 1018 cells. One clone (AK-I) expressing a similar number of kinase-inactive receptors as in the HIRc cells displayed maximal responsiveness of 3.6- to 5.5-fold increases. A second A/K cell line containing 1/10 the number of kinase-inactive receptors displayed responsiveness intermediate between AK-I and parental or HIRc cells (1.5- to 4.8-fold increases). Both clones of kinase-deficient A/K1018 cells displayed impaired insulin sensitivity compared with HIRc cells. These findings suggest that expression of insulin receptor kinase activity is a determinant of insulin sensitivity but not necessarily of the final biological responsiveness of cells to insulin. | lld:pubmed |
| pubmed-article:7534700 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7534700 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534700 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7534700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534700 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7534700 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7534700 | pubmed:issn | 0013-7227 | lld:pubmed |
| pubmed-article:7534700 | pubmed:author | pubmed-author:CiaraldiT PTP | lld:pubmed |
| pubmed-article:7534700 | pubmed:author | pubmed-author:WangS LSL | lld:pubmed |
| pubmed-article:7534700 | pubmed:author | pubmed-author:TanC HCH | lld:pubmed |
| pubmed-article:7534700 | pubmed:author | pubmed-author:LiuK TKT | lld:pubmed |
| pubmed-article:7534700 | pubmed:author | pubmed-author:KhooH EHE | lld:pubmed |
| pubmed-article:7534700 | pubmed:author | pubmed-author:NgF HFH | lld:pubmed |
| pubmed-article:7534700 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7534700 | pubmed:volume | 136 | lld:pubmed |
| pubmed-article:7534700 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7534700 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7534700 | pubmed:pagination | 1459-67 | lld:pubmed |
| pubmed-article:7534700 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:7534700 | pubmed:meshHeading | pubmed-meshheading:7534700-... | lld:pubmed |
| pubmed-article:7534700 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7534700 | pubmed:articleTitle | Rat fibroblast cells overexpressing kinase-inactive human insulin receptors are insulin responsive: influence of growth conditions. | lld:pubmed |
| pubmed-article:7534700 | pubmed:affiliation | Department of Biochemistry, National University of Singapore, Kent Ridge. | lld:pubmed |
| pubmed-article:7534700 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7534700 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:7534700 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7534700 | lld:pubmed |
