| pubmed-article:7534372 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7534372 | lifeskim:mentions | umls-concept:C0995745 | lld:lifeskim |
| pubmed-article:7534372 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:7534372 | lifeskim:mentions | umls-concept:C1623179 | lld:lifeskim |
| pubmed-article:7534372 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:7534372 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7534372 | pubmed:dateCreated | 1995-4-17 | lld:pubmed |
| pubmed-article:7534372 | pubmed:abstractText | The tylosin producer Streptomyces fradiae contains four known resistance genes, two of which (tlrA and tlrD) encode methyltransferases that act on ribosomal RNA at a common site. Expression of tlrA is regulated via transcriptional attenuation. A short transcript, only 411 nucleotides long, terminates 27 nucleotides into the methylase-coding sequence in the uninduced state. Induction of tlrA is proposed to involve a ribosome-mediated conformational change within the mRNA leader that allows transcription to continue beyond the attenuation site, resulting in a transcript about 1450 nucleotides long. Transplantation of tlrD and/or tlrA into Streptomyces albus revealed that the induction specificity of tlrA depends upon the state of the ribosomes and is significantly altered in strains also expressing tlrD. | lld:pubmed |
| pubmed-article:7534372 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7534372 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534372 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7534372 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534372 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534372 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534372 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534372 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534372 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534372 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534372 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7534372 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7534372 | pubmed:issn | 0950-382X | lld:pubmed |
| pubmed-article:7534372 | pubmed:author | pubmed-author:CundliffeEE | lld:pubmed |
| pubmed-article:7534372 | pubmed:author | pubmed-author:SenoE TET | lld:pubmed |
| pubmed-article:7534372 | pubmed:author | pubmed-author:ZalacainMM | lld:pubmed |
| pubmed-article:7534372 | pubmed:author | pubmed-author:KelemenG HGH | lld:pubmed |
| pubmed-article:7534372 | pubmed:author | pubmed-author:CulebrasEE | lld:pubmed |
| pubmed-article:7534372 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7534372 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:7534372 | pubmed:geneSymbol | tlrA | lld:pubmed |
| pubmed-article:7534372 | pubmed:geneSymbol | tlrD | lld:pubmed |
| pubmed-article:7534372 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7534372 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7534372 | pubmed:pagination | 833-42 | lld:pubmed |
| pubmed-article:7534372 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7534372 | pubmed:meshHeading | pubmed-meshheading:7534372-... | lld:pubmed |
| pubmed-article:7534372 | pubmed:meshHeading | pubmed-meshheading:7534372-... | lld:pubmed |
| pubmed-article:7534372 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7534372 | pubmed:articleTitle | Transcriptional attenuation control of the tylosin-resistance gene tlrA in Streptomyces fradiae. | lld:pubmed |
| pubmed-article:7534372 | pubmed:affiliation | Department of Biochemistry, University of Leicester, UK. | lld:pubmed |
| pubmed-article:7534372 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7534372 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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