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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1995-4-13
|
| pubmed:abstractText |
p53 protein levels are frequently elevated in basal (BCC) and squamous (SCC) cell carcinomas of UV-exposed sites. As recent findings in benign epidermal neoplasia (BEN) and normal epidermis (NE) are controversial, our aim was to look by immunohistochemistry for elevated p53 levels in NE (n = 52), reactive hyperplastic epidermis (REH, n = 8), BEN (n = 48), actinic keratosis (AK, n = 60), SCC (n = 13), and BCC (n = 42) of sun-exposed sites. 81.7% of AK, 100% of SCC, 73.8% of BCC as well as 29.2% of BEN, 37.5% of REH, and 26.9% of NE showed p53 positivity. The results further support that p53 elevated levels are an early marker of UV-mediated epidermal DNA damage.
|
| pubmed:language |
ger
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0070-4113
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
78
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
246-51
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7533993-Carcinoma, Basal Cell,
pubmed-meshheading:7533993-Carcinoma, Squamous Cell,
pubmed-meshheading:7533993-Epidermis,
pubmed-meshheading:7533993-Gene Expression,
pubmed-meshheading:7533993-Humans,
pubmed-meshheading:7533993-Hyperplasia,
pubmed-meshheading:7533993-Immunohistochemistry,
pubmed-meshheading:7533993-Keratosis,
pubmed-meshheading:7533993-Skin,
pubmed-meshheading:7533993-Skin Neoplasms,
pubmed-meshheading:7533993-Sunlight,
pubmed-meshheading:7533993-Tumor Suppressor Protein p53
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
[Elevated p53 protein expression in normal and neoplastic light-exposed epidermis].
|
| pubmed:affiliation |
Abteilung für Umweltpathologie, Heinrich-Heine-Universität Düsseldorf.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
|