| pubmed-article:7533899 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7533899 | lifeskim:mentions | umls-concept:C0009015 | lld:lifeskim |
| pubmed-article:7533899 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:7533899 | lifeskim:mentions | umls-concept:C0814023 | lld:lifeskim |
| pubmed-article:7533899 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:7533899 | lifeskim:mentions | umls-concept:C0040818 | lld:lifeskim |
| pubmed-article:7533899 | lifeskim:mentions | umls-concept:C0036319 | lld:lifeskim |
| pubmed-article:7533899 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7533899 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:7533899 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:7533899 | lifeskim:mentions | umls-concept:C0997947 | lld:lifeskim |
| pubmed-article:7533899 | pubmed:dateCreated | 1995-4-7 | lld:pubmed |
| pubmed-article:7533899 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7533899 | pubmed:abstractText | We have isolated a cDNA (SKv1.1) encoding a Shaker-related K+ channel from an adult cDNA library of the human parasitic trematode Schistosoma mansoni. The deduced amino acid sequence (512 aa, 56.5 kDa) contains 6 putative membrane-spanning domains (S1-S6) and a pore-forming domain (H5). SKv1.1 is grouped in the Shaker family, but forms a unique branch within this family, on the basis of dendrogram analysis. SKv1.1 shows significant sequence identity with most other Shaker channels, with 64-74% identity in the core region (S1-S6). It has the highest sequence identity with the K+ channel (Ak01a) from Aplysia. Northern blot analysis detected a single primary transcript of 2.8 kb. Southern blot analysis indicated that SKv1.1 is present as a single copy in the genomic DNA of S. mansoni. Expression of SKv1.1 in Xenopus oocytes produced a rapidly activating and inactivating outward K+ current which is highly sensitive to 4-aminopyridine, but is insensitive to tetraethylammonium, mast cell degranulating peptide, dendrotoxin and charybdotoxin. The presence of a Shaker homologue in Schistosoma suggests that Sh subfamilies may exist in other lower invertebrates as well as platyhelminths. | lld:pubmed |
| pubmed-article:7533899 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7533899 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7533899 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7533899 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7533899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7533899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7533899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7533899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7533899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7533899 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7533899 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:7533899 | pubmed:issn | 0031-1820 | lld:pubmed |
| pubmed-article:7533899 | pubmed:author | pubmed-author:BennettJ LJL | lld:pubmed |
| pubmed-article:7533899 | pubmed:author | pubmed-author:PaxR ARA | lld:pubmed |
| pubmed-article:7533899 | pubmed:author | pubmed-author:KimEE | lld:pubmed |
| pubmed-article:7533899 | pubmed:author | pubmed-author:DasT KTK | lld:pubmed |
| pubmed-article:7533899 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7533899 | pubmed:volume | 110 ( Pt 2) | lld:pubmed |
| pubmed-article:7533899 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7533899 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7533899 | pubmed:pagination | 171-80 | lld:pubmed |
| pubmed-article:7533899 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:7533899 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7533899 | pubmed:articleTitle | Cloning and functional expression of a Shaker-related voltage-gated potassium channel gene from Schistosoma mansoni (Trematoda: Digenea). | lld:pubmed |
| pubmed-article:7533899 | pubmed:affiliation | Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824. | lld:pubmed |
| pubmed-article:7533899 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7533899 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7533899 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7533899 | lld:pubmed |
