Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1995-3-29
pubmed:abstractText
The usefulness of the gluconeogenic key enzyme fructose 1,6 bisphosphatase (FBPase), which is localized exclusively in the proximal nephron segment, as a marker compound to monitor injury of the proximal nephron segment during nephrotoxic therapy, was tested in a collective model of male patients treated for testicular cancer. These patients with normal kidney function were submitted to therapy with the nephrotoxic chemotherapeutics carboplatinum and a combination of cisplatinum, etoposide, bleomycin and ifosfamide. The release of FBPase activities into the urine was monitored during the initial two treatments over a period of eight days. The urinary enzyme activities measured were compared to the excretion of the "proximal tubular injury markers" N-acetyl-beta-D-glucosaminidase (NAG) and alpha 1-microglobulin (alpha 1m). The presence of glomerular damage was determined by measurement of urinary excretion rates of albumin (ALB) and IgG. In addition, protein excretion patterns following chemotherapy were monitored. The combined administration of cisplatin, etoposide and ifosfamide resulted in a pronounced proximal tubular injury as shown by the release of FBPase into the urine. This is substantiated by simultaneously increased excretion rates for NAG and alpha 1m. Proximal tubular toxicity was found to be less severe when cisplatin was combined with etoposide and bleomycin and was nearly absent following carboplatinum monotherapy. Carboplatinum only affected glomerular function and resulted in an elevated ALB and IgG excretion. From this model investigation it can be delineated that determination of urinary FBPase activities ensures a sensitive and reliable identification of proximal nephron damage.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Acetylglucosaminidase, http://linkedlifedata.com/resource/pubmed/chemical/Alpha-Globulins, http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers, http://linkedlifedata.com/resource/pubmed/chemical/Bleomycin, http://linkedlifedata.com/resource/pubmed/chemical/Carboplatin, http://linkedlifedata.com/resource/pubmed/chemical/Cisplatin, http://linkedlifedata.com/resource/pubmed/chemical/Etoposide, http://linkedlifedata.com/resource/pubmed/chemical/Fructose-Bisphosphatase, http://linkedlifedata.com/resource/pubmed/chemical/Ifosfamide, http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G, http://linkedlifedata.com/resource/pubmed/chemical/alpha-1-microglobulin
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0098-6577
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S68-75
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:7532742-Acetylglucosaminidase, pubmed-meshheading:7532742-Adolescent, pubmed-meshheading:7532742-Adult, pubmed-meshheading:7532742-Albuminuria, pubmed-meshheading:7532742-Alpha-Globulins, pubmed-meshheading:7532742-Antineoplastic Agents, pubmed-meshheading:7532742-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:7532742-Biological Markers, pubmed-meshheading:7532742-Bleomycin, pubmed-meshheading:7532742-Carboplatin, pubmed-meshheading:7532742-Cisplatin, pubmed-meshheading:7532742-Etoposide, pubmed-meshheading:7532742-Fructose-Bisphosphatase, pubmed-meshheading:7532742-Humans, pubmed-meshheading:7532742-Ifosfamide, pubmed-meshheading:7532742-Immunoglobulin G, pubmed-meshheading:7532742-Kidney Tubules, Proximal, pubmed-meshheading:7532742-Male, pubmed-meshheading:7532742-Middle Aged, pubmed-meshheading:7532742-Testicular Neoplasms
pubmed:year
1994
pubmed:articleTitle
Clinical value of fructose 1,6 bisphosphatase in monitoring renal proximal tubular injury.
pubmed:affiliation
Institute of Physiology, University of Innsbruck, Austria.
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial, Research Support, Non-U.S. Gov't