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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1995-3-29
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pubmed:abstractText |
The aim of the present study was to visualize the superficial glomeruli of the Munich-Wistar (MW) rat and to characterize the responses of the renal microvasculature to endothelin-1 (ET-1). We first examined the distribution of superficial glomeruli of the MW rat compared to that in a control strain (Wistar rat). Secondly, we examined the effects of ET-1 on the renal microcirculation of the MW rat. The right kidney was perfused with a Krebs-Ringer solution containing fluorescein isothiocyanate dextran (FITC-dextran) and was visualized under an epi-illuminated fluorescence microscope system. Changes in perfusion pressure and diameter of the microvessels accompanying the administration of ET-1 (10 fmole-300 pmole) were measured. The number of superficial glomeruli was greater in the MW rat than in the Wistar rat. ET-1 had long-lasting and dose-dependent pressor effects. Perfusion pressure showed a 3.5-fold increase compared with the control, and the afferent arterioles showed greater dose-dependent vasoconstriction than the efferent arterioles. These findings suggest that the MW rat is a useful animal model for the study of renal microcirculation and that the renal microcirculation is extremely sensitive to ET-1.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0021-5198
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
221-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7532735-Analysis of Variance,
pubmed-meshheading:7532735-Animals,
pubmed-meshheading:7532735-Dextrans,
pubmed-meshheading:7532735-Dose-Response Relationship, Drug,
pubmed-meshheading:7532735-Endothelins,
pubmed-meshheading:7532735-Fluorescein-5-isothiocyanate,
pubmed-meshheading:7532735-Hemodynamics,
pubmed-meshheading:7532735-Kidney Glomerulus,
pubmed-meshheading:7532735-Male,
pubmed-meshheading:7532735-Microcirculation,
pubmed-meshheading:7532735-Microscopy, Fluorescence,
pubmed-meshheading:7532735-Perfusion,
pubmed-meshheading:7532735-Rats,
pubmed-meshheading:7532735-Rats, Wistar,
pubmed-meshheading:7532735-Renal Circulation
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pubmed:year |
1994
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pubmed:articleTitle |
Visualization of renal microcirculation in isolated Munich-Wistar rat kidneys: effects of endothelin-1 on renal hemodynamic activity.
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pubmed:affiliation |
Tsukuba Research Laboratories, Eisai Co., Ltd., Ibaraki, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't
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