| pubmed-article:7532686 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7532686 | lifeskim:mentions | umls-concept:C0024299 | lld:lifeskim |
| pubmed-article:7532686 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:7532686 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:7532686 | lifeskim:mentions | umls-concept:C0001455 | lld:lifeskim |
| pubmed-article:7532686 | lifeskim:mentions | umls-concept:C0259309 | lld:lifeskim |
| pubmed-article:7532686 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:7532686 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:7532686 | lifeskim:mentions | umls-concept:C1549809 | lld:lifeskim |
| pubmed-article:7532686 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7532686 | pubmed:dateCreated | 1995-3-24 | lld:pubmed |
| pubmed-article:7532686 | pubmed:abstractText | K46J B lymphomas express a T cell costimulatory activity that is not inhibited by CTLA-4Ig, anti-B7-1, anti-B7-2, anti-intercellular adhesion molecule 1 or antibodies to heat stable antigen. In this paper we report that this costimulatory activity is mediated at least in part by 4-1BB ligand, a member of the tumor necrosis factor (TNF) gene family that binds to 4-1BB, a T cell activation antigen with homology to the TNF/nerve growth factor receptor family. A fusion protein between 4-1BB and alkaline phosphatase (4-1BB-AP) blocks T cell activation by K46J lymphomas in both an antigen-specific system and with polyclonally (anti-CD3) activated T cells. 4-1BB-AP also blocks antigen presentation by normal spleen cells. When the antigen-presenting cells express B7 molecules as well as 4-1BB ligand, we find that B7 molecules and 4-1BB-AP both contribute to T cell activation. These data suggest that 4-1BB ligand plays an important role in costimulation of IL-2 production and proliferation by T cells. The B lymphoma M12 expresses low levels of 4-1BB-L but can be induced to express higher levels by treatment of the B cells with cAMP, which also induces B7-1 and B7-2 in these cells. Thus cAMP appears to coordinately induce several costimulatory molecules on B cells. | lld:pubmed |
| pubmed-article:7532686 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7532686 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7532686 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532686 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7532686 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:7532686 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:7532686 | pubmed:author | pubmed-author:WattsT HTH | lld:pubmed |
| pubmed-article:7532686 | pubmed:author | pubmed-author:KwonB SBS | lld:pubmed |
| pubmed-article:7532686 | pubmed:author | pubmed-author:HurtadoJJ | lld:pubmed |
| pubmed-article:7532686 | pubmed:author | pubmed-author:PollokK EKE | lld:pubmed |
| pubmed-article:7532686 | pubmed:author | pubmed-author:PanJ CJC | lld:pubmed |
| pubmed-article:7532686 | pubmed:author | pubmed-author:WadeW FWF | lld:pubmed |
| pubmed-article:7532686 | pubmed:author | pubmed-author:DeBenedetteM... | lld:pubmed |
| pubmed-article:7532686 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7532686 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7532686 | pubmed:volume | 181 | lld:pubmed |
| pubmed-article:7532686 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7532686 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7532686 | pubmed:pagination | 985-92 | lld:pubmed |
| pubmed-article:7532686 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:7532686 | pubmed:meshHeading | pubmed-meshheading:7532686-... | lld:pubmed |
| pubmed-article:7532686 | pubmed:meshHeading | pubmed-meshheading:7532686-... | lld:pubmed |
| pubmed-article:7532686 | pubmed:meshHeading | pubmed-meshheading:7532686-... | lld:pubmed |
| pubmed-article:7532686 | pubmed:meshHeading | pubmed-meshheading:7532686-... | lld:pubmed |
| pubmed-article:7532686 | pubmed:meshHeading | pubmed-meshheading:7532686-... | lld:pubmed |
| pubmed-article:7532686 | pubmed:meshHeading | pubmed-meshheading:7532686-... | lld:pubmed |
| pubmed-article:7532686 | pubmed:meshHeading | pubmed-meshheading:7532686-... | lld:pubmed |
| pubmed-article:7532686 | pubmed:meshHeading | pubmed-meshheading:7532686-... | lld:pubmed |
| pubmed-article:7532686 | pubmed:meshHeading | pubmed-meshheading:7532686-... | lld:pubmed |
| pubmed-article:7532686 | pubmed:meshHeading | pubmed-meshheading:7532686-... | lld:pubmed |
| pubmed-article:7532686 | pubmed:meshHeading | pubmed-meshheading:7532686-... | lld:pubmed |
| pubmed-article:7532686 | pubmed:meshHeading | pubmed-meshheading:7532686-... | lld:pubmed |
| pubmed-article:7532686 | pubmed:meshHeading | pubmed-meshheading:7532686-... | lld:pubmed |
| pubmed-article:7532686 | pubmed:meshHeading | pubmed-meshheading:7532686-... | lld:pubmed |
| pubmed-article:7532686 | pubmed:meshHeading | pubmed-meshheading:7532686-... | lld:pubmed |
| pubmed-article:7532686 | pubmed:meshHeading | pubmed-meshheading:7532686-... | lld:pubmed |
