Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-3-24
pubmed:abstractText
K46J B lymphomas express a T cell costimulatory activity that is not inhibited by CTLA-4Ig, anti-B7-1, anti-B7-2, anti-intercellular adhesion molecule 1 or antibodies to heat stable antigen. In this paper we report that this costimulatory activity is mediated at least in part by 4-1BB ligand, a member of the tumor necrosis factor (TNF) gene family that binds to 4-1BB, a T cell activation antigen with homology to the TNF/nerve growth factor receptor family. A fusion protein between 4-1BB and alkaline phosphatase (4-1BB-AP) blocks T cell activation by K46J lymphomas in both an antigen-specific system and with polyclonally (anti-CD3) activated T cells. 4-1BB-AP also blocks antigen presentation by normal spleen cells. When the antigen-presenting cells express B7 molecules as well as 4-1BB ligand, we find that B7 molecules and 4-1BB-AP both contribute to T cell activation. These data suggest that 4-1BB ligand plays an important role in costimulation of IL-2 production and proliferation by T cells. The B lymphoma M12 expresses low levels of 4-1BB-L but can be induced to express higher levels by treatment of the B cells with cAMP, which also induces B7-1 and B7-2 in these cells. Thus cAMP appears to coordinately induce several costimulatory molecules on B cells.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-1279442, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-1279676, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-1346270, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-1370349, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-1372018, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-1373896, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-1385153, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-1653571, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-1680921, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-1714933, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-1847722, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-2473111, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-2500256, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-2503831, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-2571505, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-2653373, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-2918224, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-2950524, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-310843, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-6334313, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-7504059, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-7513726, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-7522010, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-7678621, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-7680686, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-7694361, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-7908303, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-7917108, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-8086099, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-8294884, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-8299685, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-8335927, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-8386518, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-8387892, http://linkedlifedata.com/resource/pubmed/commentcorrection/7532686-8405064
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/4-1BB Ligand, http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation, http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen, http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP, http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates, http://linkedlifedata.com/resource/pubmed/chemical/Ligands, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Nerve Growth Factor, http://linkedlifedata.com/resource/pubmed/chemical/Tnfsf9 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha, http://linkedlifedata.com/resource/pubmed/chemical/abatacept
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
181
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
985-92
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
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