Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1995-3-30
pubmed:abstractText
Recurrence of gestational trophoblastic disease (GTD) following two attempts at in-vitro fertilization (IVF)/embryo transfer is reported in a childless couple after 17 years of unsuccessful trials of ovulation induction. The diagnosis of bilateral tubal obstruction was finally established, indicating IVF treatment. After the first IVF/embryo transfer treatment, the woman developed GTD and was treated with methotrexate. After a second IVF attempt, GTD was again diagnosed. This time there was no response to methotrexate, thus necessitating second-line chemotherapy. Etoposide, methotrexate, actinomycin D, cyclophosphamide, oncovine was used, and after only four treatment cycles the beta-human chorionic gonadotrophin (HCG) dropped to < 5 mIU/ml. After 26 months of follow-up, the beta-HCG continues to be undetectable. Preimplantation evaluation and ovum donation are described as measures to minimize the risk for GTD recurrence in a future IVF/embryo transfer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0268-1161
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2010-3
pubmed:dateRevised
2006-4-24
pubmed:meshHeading
pubmed-meshheading:7532652-Adult, pubmed-meshheading:7532652-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:7532652-Chorionic Gonadotropin, pubmed-meshheading:7532652-Chorionic Gonadotropin, beta Subunit, Human, pubmed-meshheading:7532652-Cyclophosphamide, pubmed-meshheading:7532652-Dactinomycin, pubmed-meshheading:7532652-Embryo Transfer, pubmed-meshheading:7532652-Etoposide, pubmed-meshheading:7532652-Female, pubmed-meshheading:7532652-Fertilization in Vitro, pubmed-meshheading:7532652-Humans, pubmed-meshheading:7532652-Infertility, Female, pubmed-meshheading:7532652-Methotrexate, pubmed-meshheading:7532652-Peptide Fragments, pubmed-meshheading:7532652-Pregnancy, pubmed-meshheading:7532652-Recurrence, pubmed-meshheading:7532652-Trophoblastic Neoplasms, pubmed-meshheading:7532652-Uterine Neoplasms, pubmed-meshheading:7532652-Vincristine
pubmed:year
1994
pubmed:articleTitle
Recurrent gestational trophoblastic disease following in-vitro fertilization.
pubmed:affiliation
Department of Obstetrics and Gynaecology, Hadassah Medical Centre, Hebrew University Medical School, Jerusalem, Israel.
pubmed:publicationType
Journal Article, Case Reports