Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1995-3-15
pubmed:abstractText
The contractile effects of the tachykinins eledoisin, substance P and neurokinin A and B were investigated in vitro on circular and longitudinal muscle strips from horse duodenum, ileum and colon. Circular smooth muscle of the small intestine was highly responsive, large intestine circular smooth muscle less so, while longitudinal muscle from all gut segments was much less sensitive. pD2 values and intrinsic activities on small intestine circular muscle indicated differences in receptor distribution between the duodenum and ileum: NK3 and a smaller number of NK2 receptors being present in the duodenum, and NK2 receptors predominating in the ileum. Notwithstanding this, eledoisin and neurokinin B were the most active substances on duodenum and ileum, respectively. These findings suggest that tachykinins may play a role in equine gastrointestinal pathophysiology.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0140-7783
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
379-83
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:7531778-Analysis of Variance, pubmed-meshheading:7531778-Animals, pubmed-meshheading:7531778-Atropine, pubmed-meshheading:7531778-Colon, pubmed-meshheading:7531778-Dose-Response Relationship, Drug, pubmed-meshheading:7531778-Duodenum, pubmed-meshheading:7531778-Electrophysiology, pubmed-meshheading:7531778-Eledoisin, pubmed-meshheading:7531778-Horses, pubmed-meshheading:7531778-Ileum, pubmed-meshheading:7531778-Muscle, Smooth, pubmed-meshheading:7531778-Muscle Contraction, pubmed-meshheading:7531778-Neurokinin A, pubmed-meshheading:7531778-Neurokinin B, pubmed-meshheading:7531778-Receptors, Neurokinin-2, pubmed-meshheading:7531778-Receptors, Neurokinin-3, pubmed-meshheading:7531778-Regression Analysis, pubmed-meshheading:7531778-Substance P, pubmed-meshheading:7531778-Tetrodotoxin
pubmed:year
1994
pubmed:articleTitle
In vitro effects of tachykinins on the smooth musculature of horse gut.
pubmed:affiliation
Institute of Veterinary Pharmacology & Toxicology, Faculty of Veterinary Medicine, Milan, Italy.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't