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pubmed-article:7531596pubmed:abstractTextNorepinephrine (NE)-induced potentiation of the perforant path-evoked potential is blocked by N-methyl-D-aspartate (NMDA) receptor antagonism in vitro. Does this occur in vivo? A saline and a ketamine micropipette monitored perforant path-evoked potentials in the dentate gyrus of urethane-anesthetized rats. Activation of locus coeruleus (LC) produced short- and long-term potentiation of the perforant path-evoked potential on both pipettes. Spike amplitude potentiation was enhanced on the ketamine pipette. In contrast high frequency-induced potentiation on the ketamine pipette was attenuated. LC-NE potentiation may not require NMDA channel activation in vivo.lld:pubmed
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pubmed-article:7531596pubmed:articleTitleThe N-methyl-D-aspartate channel blocker ketamine does not attenuate, but enhances, locus coeruleus-induced potentiation in rat dentate gyrus.lld:pubmed
pubmed-article:7531596pubmed:affiliationPsychology Department, Memorial University of Newfoundland, St. John's, Canada.lld:pubmed
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