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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1995-3-14
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pubmed:abstractText |
Norepinephrine (NE)-induced potentiation of the perforant path-evoked potential is blocked by N-methyl-D-aspartate (NMDA) receptor antagonism in vitro. Does this occur in vivo? A saline and a ketamine micropipette monitored perforant path-evoked potentials in the dentate gyrus of urethane-anesthetized rats. Activation of locus coeruleus (LC) produced short- and long-term potentiation of the perforant path-evoked potential on both pipettes. Spike amplitude potentiation was enhanced on the ketamine pipette. In contrast high frequency-induced potentiation on the ketamine pipette was attenuated. LC-NE potentiation may not require NMDA channel activation in vivo.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0006-8993
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
663
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
173-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7531596-Animals,
pubmed-meshheading:7531596-Brain Mapping,
pubmed-meshheading:7531596-Electric Stimulation,
pubmed-meshheading:7531596-Evoked Potentials,
pubmed-meshheading:7531596-Hippocampus,
pubmed-meshheading:7531596-Ion Channels,
pubmed-meshheading:7531596-Ketamine,
pubmed-meshheading:7531596-Locus Coeruleus,
pubmed-meshheading:7531596-Long-Term Potentiation,
pubmed-meshheading:7531596-Male,
pubmed-meshheading:7531596-Norepinephrine,
pubmed-meshheading:7531596-Rats,
pubmed-meshheading:7531596-Rats, Sprague-Dawley,
pubmed-meshheading:7531596-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:7531596-Time Factors
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pubmed:year |
1994
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pubmed:articleTitle |
The N-methyl-D-aspartate channel blocker ketamine does not attenuate, but enhances, locus coeruleus-induced potentiation in rat dentate gyrus.
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pubmed:affiliation |
Psychology Department, Memorial University of Newfoundland, St. John's, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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