Linked Life Data

7531190

Source:http://linkedlifedata.com/resource/pubmed/id/7531190

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1995-3-3
pubmed:abstractText
The innervation of the cat lower oesophagus, including the lower oesophageal sphincter, was studied by enzyme histochemistry, immunohistochemistry, and confocal microscopy. In the lower oesophageal sphincter, and at a level 2 cm above it, no apparent differences were seen in the nerve distribution pattern. Among the nerve populations studied, acetylcholinesterase (AChE)-positive nerves were the most abundant in both these regions. The density of AChE-positive nerves was particularly marked in the circular muscle layer. A rich supply of nitric oxide synthase (NOS)-containing nerves was identified by using an antiserum against neuronal NOS, or by enzyme histochemical staining for NADPH diaphorase activity. Vasoactive intestinal peptide (VIP)-immunoreactive nerves had a similar distribution pattern as NOS-immunoreactive nerves, and nerves displaying immunoreactivity for NOS and VIP often showed profiles coinciding with AChE-positive nerves. As judged by confocal microscopy, immunoreactivities for helospectin, pituitary adenylate cyclase-activating peptide (PACAP) and VIP, to a large extent were found in the same nerves. At a level 7 cm above the lower oesophageal sphincter, the total nerve supply was less than in the sphincter itself and 2 cm above it. Immunoreactivity towards VIP, PACAP and helospectin was also found to co-exist with NOS and neuropeptide Y within the same nerve structures. It is concluded that there is an intricate innervation pattern in the feline lower oesophagus reflecting the complexity in the regulation of its motility.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0018-2214
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
721-33
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:7531190-Acetylcholinesterase, pubmed-meshheading:7531190-Adrenergic Fibers, pubmed-meshheading:7531190-Amino Acid Oxidoreductases, pubmed-meshheading:7531190-Animals, pubmed-meshheading:7531190-Cats, pubmed-meshheading:7531190-Cholinergic Fibers, pubmed-meshheading:7531190-Esophagogastric Junction, pubmed-meshheading:7531190-Esophagus, pubmed-meshheading:7531190-Immunohistochemistry, pubmed-meshheading:7531190-Male, pubmed-meshheading:7531190-Microscopy, Confocal, pubmed-meshheading:7531190-Nerve Tissue, pubmed-meshheading:7531190-Neuropeptide Y, pubmed-meshheading:7531190-Neuropeptides, pubmed-meshheading:7531190-Neurotransmitter Agents, pubmed-meshheading:7531190-Nitric Oxide Synthase, pubmed-meshheading:7531190-Peptides, pubmed-meshheading:7531190-Pituitary Adenylate Cyclase-Activating Polypeptide, pubmed-meshheading:7531190-Tyrosine 3-Monooxygenase, pubmed-meshheading:7531190-Vasoactive Intestinal Peptide
pubmed:year
1994
pubmed:articleTitle
Nitric oxide synthase-containing, peptide-containing, and acetylcholinesterase-positive nerves in the cat lower oesophagus.
pubmed:affiliation
Department of Clinical Pharmacology, University of Lund, Lund University Hospital, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't