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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1995-3-2
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pubmed:abstractText |
Under FK506-based immunosuppression, 13 abdominal multivisceral transplantations were performed in 6 children and 7 adults. Of the 13 recipients, 7 (53.8%) are alive and well with functioning grafts after 9 to 31 months. Six recipients died: three from PTLD, one from rejection, one from sepsis, and one from respiratory failure. In addition to rejection, postoperative complications occurring in more than isolated cases included PTLD (n = 6), abdominal abscess formation (n = 5), pancreatitis (n = 3), and ampullary dysfunction (n = 2). In addition, infection by enteric microorganisms was common during the early postoperative period. Currently, all 7 survivors are on an oral diet and have normal liver function. Two recipients (one insulin-dependent) require antidiabetes treatment, in one case following distal pancreatectomy and in the other after two episodes of pancreatic rejection. Thus, abdominal multivisceral transplantation is a difficult but feasible operation that demands complex and prolonged posttransplantation management. It is not yet ready for application and awaits a better strategy of immune modulation.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
|
pubmed:issn |
0041-1337
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
27
|
pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
234-40
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pubmed:dateRevised |
2010-12-3
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pubmed:meshHeading |
pubmed-meshheading:7530873-Abdomen,
pubmed-meshheading:7530873-Adult,
pubmed-meshheading:7530873-Child,
pubmed-meshheading:7530873-Child, Preschool,
pubmed-meshheading:7530873-Digestive System Surgical Procedures,
pubmed-meshheading:7530873-Graft Rejection,
pubmed-meshheading:7530873-Humans,
pubmed-meshheading:7530873-Infant,
pubmed-meshheading:7530873-Intestines,
pubmed-meshheading:7530873-Lymphoproliferative Disorders,
pubmed-meshheading:7530873-Middle Aged,
pubmed-meshheading:7530873-Survival Analysis,
pubmed-meshheading:7530873-Tacrolimus,
pubmed-meshheading:7530873-Viscera
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pubmed:year |
1995
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pubmed:articleTitle |
Abdominal multivisceral transplantation.
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pubmed:affiliation |
Pittsburgh Transplantation Institute, University of Pittsburgh Medical Center, Pennsylvania 15213.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.
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