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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6512
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pubmed:dateCreated |
1995-2-17
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pubmed:abstractText |
The 2.3-A crystal structure of the transcription factor NK-kappa B p50 homodimer bound to a palindromic kappa B site reveals that the Rel homology region folds into two distinct domains, similar to those in the immunoglobulin superfamily. The p50 dimer envelopes an undistorted B-DNA helix, making specific contacts along the 10-base-pair kappa B recognition site mainly through loops connecting secondary structure elements in both domains. The carboxy-terminal domains form a dimerization interface between beta-sheets using residues that are strongly conserved in the Rel family.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
373
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
303-10
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7530332-Amino Acid Sequence,
pubmed-meshheading:7530332-Animals,
pubmed-meshheading:7530332-Base Sequence,
pubmed-meshheading:7530332-Computer Graphics,
pubmed-meshheading:7530332-Crystallography, X-Ray,
pubmed-meshheading:7530332-DNA,
pubmed-meshheading:7530332-Drosophila,
pubmed-meshheading:7530332-Humans,
pubmed-meshheading:7530332-Immunoglobulins,
pubmed-meshheading:7530332-Mice,
pubmed-meshheading:7530332-Molecular Sequence Data,
pubmed-meshheading:7530332-NF-kappa B,
pubmed-meshheading:7530332-NF-kappa B p50 Subunit,
pubmed-meshheading:7530332-Nucleic Acid Conformation,
pubmed-meshheading:7530332-Protein Binding,
pubmed-meshheading:7530332-Protein Conformation,
pubmed-meshheading:7530332-Proto-Oncogene Proteins,
pubmed-meshheading:7530332-Proto-Oncogene Proteins c-rel,
pubmed-meshheading:7530332-RNA,
pubmed-meshheading:7530332-Sequence Homology, Amino Acid
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pubmed:year |
1995
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pubmed:articleTitle |
Structure of NF-kappa B p50 homodimer bound to a kappa B site.
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pubmed:affiliation |
Howard Hughes Medical Institute, Yale University, New Haven, Connecticut 06510.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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