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| pubmed-article:7530250 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:7530250 | lifeskim:mentions | umls-concept:C0521346 | lld:lifeskim |
| pubmed-article:7530250 | lifeskim:mentions | umls-concept:C1550271 | lld:lifeskim |
| pubmed-article:7530250 | lifeskim:mentions | umls-concept:C0006556 | lld:lifeskim |
| pubmed-article:7530250 | lifeskim:mentions | umls-concept:C0599635 | lld:lifeskim |
| pubmed-article:7530250 | lifeskim:mentions | umls-concept:C0009017 | lld:lifeskim |
| pubmed-article:7530250 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:7530250 | lifeskim:mentions | umls-concept:C0442040 | lld:lifeskim |
| pubmed-article:7530250 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7530250 | pubmed:dateCreated | 1995-2-22 | lld:pubmed |
| pubmed-article:7530250 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7530250 | pubmed:abstractText | The Aquaporin family of water channels plays a fundamental role in transmembrane water movements in numerous plant and animal tissues. Since the molecular pathway by which water is secreted by salivary glands is unknown, a cDNA was isolated from rat submandibular gland by homology cloning. Similar to other Aquaporins, the salivary cDNA encodes a 265-residue polypeptide with six putative transmembrane domains separated by five connecting loops (A-E); the NH2- and COOH-terminal halves of the polypeptide are sequence-related, and each contains the motif Asn-Pro-Ala. A mercurial-inhibition site is present in extracellular loop E, and cytoplasmic loop D contains a cAMP-protein kinase phosphorylation consensus. In vitro translation yielded a 27-kDa polypeptide, and expression of the cRNA in Xenopus oocytes conferred a 20-fold increase in osmotic water permeability (Pf) which was reversibly inhibited by 1 mM HgCl2. Northern analysis demonstrated a 1.6-kilobase mRNA in submandibular, parotid, and sublingual salivary glands, lacrimal gland, eye, trachea, and lung. In situ hybridization revealed a strong hybridization over the corneal epithelium in eye and over the secretory lobules in salivary glands. These studies have identified a new mammalian member of the Aquaporin water channel family (gene symbol AQP5) which is implicated in the generation of saliva, tears, and pulmonary secretions. | lld:pubmed |
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| pubmed-article:7530250 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7530250 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7530250 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7530250 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7530250 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:7530250 | pubmed:author | pubmed-author:RainaSS | lld:pubmed |
| pubmed-article:7530250 | pubmed:author | pubmed-author:PrestonG MGM | lld:pubmed |
| pubmed-article:7530250 | pubmed:author | pubmed-author:GugginoW BWB | lld:pubmed |
| pubmed-article:7530250 | pubmed:author | pubmed-author:AgrePP | lld:pubmed |
| pubmed-article:7530250 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7530250 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:7530250 | pubmed:volume | 270 | lld:pubmed |
| pubmed-article:7530250 | pubmed:geneSymbol | AQP5 | lld:pubmed |
| pubmed-article:7530250 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7530250 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7530250 | pubmed:pagination | 1908-12 | lld:pubmed |
| pubmed-article:7530250 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:7530250 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7530250 | pubmed:articleTitle | Molecular cloning and characterization of an aquaporin cDNA from salivary, lacrimal, and respiratory tissues. | lld:pubmed |
| pubmed-article:7530250 | pubmed:affiliation | Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205. | lld:pubmed |
| pubmed-article:7530250 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7530250 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7530250 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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