rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1995-2-6
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pubmed:abstractText |
We report the amplification and overexpression of the IGFIR (insulin-like growth factor I receptor) gene in primary breast cancers with an amplification of band 15q26. The involvement of IGFIR, which may vary in frequency from 2-3% in unselected tumor series to more than 10% in breast cancers with hsr, may represent an important event in tumor progression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carboxylic Ester Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/FES protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-fes,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, IGF Type 1
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1045-2257
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:geneSymbol |
IGF1R
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
63-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7529048-Blotting, Northern,
pubmed-meshheading:7529048-Blotting, Southern,
pubmed-meshheading:7529048-Breast Neoplasms,
pubmed-meshheading:7529048-Carboxylic Ester Hydrolases,
pubmed-meshheading:7529048-Chromosomes, Human, Pair 15,
pubmed-meshheading:7529048-DNA, Neoplasm,
pubmed-meshheading:7529048-Female,
pubmed-meshheading:7529048-Gene Amplification,
pubmed-meshheading:7529048-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:7529048-Humans,
pubmed-meshheading:7529048-Neoplasm Proteins,
pubmed-meshheading:7529048-Protein-Tyrosine Kinases,
pubmed-meshheading:7529048-Proto-Oncogene Proteins,
pubmed-meshheading:7529048-Proto-Oncogene Proteins c-fes,
pubmed-meshheading:7529048-RNA, Neoplasm,
pubmed-meshheading:7529048-Receptor, IGF Type 1
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pubmed:year |
1994
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pubmed:articleTitle |
The insulin-like growth factor I receptor gene is the target for the 15q26 amplicon in breast cancer.
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pubmed:affiliation |
CNRS URA 620, Institut Curie, Section de Biologie, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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