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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1995-1-25
|
| pubmed:abstractText |
The effects of single oral doses of lisinopril (5 and 20 mg) on systemic and regional hemodynamics were investigated noninvasively in a placebo-controlled, randomized, double-blind, cross-over study of 6 healthy male volunteers. Lisinopril induced a dose-dependent (significant after 20 mg) and long-lasting (< or = 8 h) decrease in mean arterial pressure (MAP, approximately 11% after 20 mg) that was related to a decrease in total peripheral resistance (TPR), because simultaneously heart rate (HR) and cardiac output (CO) were unchanged. Brachial artery flow (+42 and +47% after 5 and 20 mg, respectively) and diameter (+8 and +9%) increased significantly, whereas brachial vascular resistance (-31 and -38%) decreased significantly from 2 to 8 h after drug intake. Common carotid artery flow (+20 and +24%) also increased significantly, whereas corresponding resistance (-18 and -26%) decreased significantly during the same period. Finally, CO was significantly redistributed toward the brachial and, to a lesser extent, the carotid vascular beds after both doses of lisinopril. We conclude that in healthy subjects lisinopril, at non- or slightly hypotensive doses, dilates both arterioles and large arteries and that this vasodilation is not homogeneous, affecting preferentially the brachial rather than the carotid vascular bed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0160-2446
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
24
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
500-8
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7528307-Administration, Oral,
pubmed-meshheading:7528307-Adult,
pubmed-meshheading:7528307-Analysis of Variance,
pubmed-meshheading:7528307-Arteries,
pubmed-meshheading:7528307-Arterioles,
pubmed-meshheading:7528307-Blood Pressure,
pubmed-meshheading:7528307-Brachial Artery,
pubmed-meshheading:7528307-Cardiac Output,
pubmed-meshheading:7528307-Carotid Arteries,
pubmed-meshheading:7528307-Cross-Over Studies,
pubmed-meshheading:7528307-Dose-Response Relationship, Drug,
pubmed-meshheading:7528307-Double-Blind Method,
pubmed-meshheading:7528307-Drug Evaluation,
pubmed-meshheading:7528307-Heart Rate,
pubmed-meshheading:7528307-Hemodynamics,
pubmed-meshheading:7528307-Humans,
pubmed-meshheading:7528307-Laser-Doppler Flowmetry,
pubmed-meshheading:7528307-Lisinopril,
pubmed-meshheading:7528307-Male,
pubmed-meshheading:7528307-Regional Blood Flow,
pubmed-meshheading:7528307-Vascular Resistance,
pubmed-meshheading:7528307-Vasodilation
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Noninvasive assessment of regional arteriolar and arterial dilating properties of lisinopril in healthy volunteers.
|
| pubmed:affiliation |
Service de Pharmacologie Clinique, Hôpital de Bic?tre, Le Kremlin, France.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
|