| pubmed-article:7528102 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7528102 | lifeskim:mentions | umls-concept:C0085872 | lld:lifeskim |
| pubmed-article:7528102 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:7528102 | lifeskim:mentions | umls-concept:C0033692 | lld:lifeskim |
| pubmed-article:7528102 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:7528102 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:7528102 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:7528102 | lifeskim:mentions | umls-concept:C1156237 | lld:lifeskim |
| pubmed-article:7528102 | lifeskim:mentions | umls-concept:C0136134 | lld:lifeskim |
| pubmed-article:7528102 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:7528102 | lifeskim:mentions | umls-concept:C0178499 | lld:lifeskim |
| pubmed-article:7528102 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:7528102 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:7528102 | pubmed:dateCreated | 1995-1-26 | lld:pubmed |
| pubmed-article:7528102 | pubmed:abstractText | A survey of defined species of cell surface and extracellular matrix heparan sulfate proteoglycans (HSPG) was performed in a search for cellular proteoglycans that can promote bFGF receptor binding and biological activity. Of the various affinity-purified HSPGs tested, perlecan, the large basement membrane HSPG, is found to induce high affinity binding of bFGF both to cells deficient in HS and to soluble FGF receptors. Heparin-dependent mitogenic activity of bFGF is strongly augmented by perlecan. Monoclonal antibodies to perlecan extract the receptor binding promoting activity from active HSPG preparations. In a rabbit ear model for in vivo angiogenesis, perlecan is a potent inducer of bFGF-mediated neovascularization. These results identify perlecan as a major candidate for a bFGF low affinity, accessory receptor and an angiogenic modulator. | lld:pubmed |
| pubmed-article:7528102 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7528102 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7528102 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7528102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7528102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7528102 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7528102 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7528102 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:7528102 | pubmed:author | pubmed-author:EisingerMM | lld:pubmed |
| pubmed-article:7528102 | pubmed:author | pubmed-author:DavidGG | lld:pubmed |
| pubmed-article:7528102 | pubmed:author | pubmed-author:YayonAA | lld:pubmed |
| pubmed-article:7528102 | pubmed:author | pubmed-author:SafranMM | lld:pubmed |
| pubmed-article:7528102 | pubmed:author | pubmed-author:HechtDD | lld:pubmed |
| pubmed-article:7528102 | pubmed:author | pubmed-author:AviezerDD | lld:pubmed |
| pubmed-article:7528102 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7528102 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:7528102 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:7528102 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7528102 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7528102 | pubmed:pagination | 1005-13 | lld:pubmed |
| pubmed-article:7528102 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7528102 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7528102 | pubmed:articleTitle | Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis. | lld:pubmed |
| pubmed-article:7528102 | pubmed:affiliation | Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel. | lld:pubmed |
| pubmed-article:7528102 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7528102 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:7528102 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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