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rdf:type |
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lifeskim:mentions |
umls-concept:C0016030,
umls-concept:C0018270,
umls-concept:C0033414,
umls-concept:C0033692,
umls-concept:C0085872,
umls-concept:C0136134,
umls-concept:C0178499,
umls-concept:C0302600,
umls-concept:C1156237,
umls-concept:C1167622,
umls-concept:C1527178
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pubmed:issue |
6
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|
pubmed:dateCreated |
1995-1-26
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pubmed:abstractText |
A survey of defined species of cell surface and extracellular matrix heparan sulfate proteoglycans (HSPG) was performed in a search for cellular proteoglycans that can promote bFGF receptor binding and biological activity. Of the various affinity-purified HSPGs tested, perlecan, the large basement membrane HSPG, is found to induce high affinity binding of bFGF both to cells deficient in HS and to soluble FGF receptors. Heparin-dependent mitogenic activity of bFGF is strongly augmented by perlecan. Monoclonal antibodies to perlecan extract the receptor binding promoting activity from active HSPG preparations. In a rabbit ear model for in vivo angiogenesis, perlecan is a potent inducer of bFGF-mediated neovascularization. These results identify perlecan as a major candidate for a bFGF low affinity, accessory receptor and an angiogenic modulator.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0092-8674
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1005-13
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7528102-Animals,
pubmed-meshheading:7528102-Basement Membrane,
pubmed-meshheading:7528102-CHO Cells,
pubmed-meshheading:7528102-Cell Division,
pubmed-meshheading:7528102-Cricetinae,
pubmed-meshheading:7528102-Dose-Response Relationship, Drug,
pubmed-meshheading:7528102-Ear,
pubmed-meshheading:7528102-Extracellular Matrix,
pubmed-meshheading:7528102-Female,
pubmed-meshheading:7528102-Fibroblast Growth Factor 2,
pubmed-meshheading:7528102-Heparan Sulfate Proteoglycans,
pubmed-meshheading:7528102-Heparitin Sulfate,
pubmed-meshheading:7528102-Humans,
pubmed-meshheading:7528102-Lung,
pubmed-meshheading:7528102-Neovascularization, Pathologic,
pubmed-meshheading:7528102-Protein Binding,
pubmed-meshheading:7528102-Proteoglycans,
pubmed-meshheading:7528102-Rabbits,
pubmed-meshheading:7528102-Receptors, Fibroblast Growth Factor
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pubmed:year |
1994
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pubmed:articleTitle |
Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis.
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|
pubmed:affiliation |
Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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