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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1995-1-13
|
| pubmed:abstractText |
Peripheral T-cell lymphomas comprise a heterogenous group of low- and high-grade malignancies differing in their histopathological appearance and also in clinical and prognostic aspects. We prospectively studied 25 patients with low-grade peripheral T-cell lymphomas: pleomorphic, small cell lymphoma (PSC) (n = 9), lymphoepitheloid (Lennert's) lymphoma (LEL) (n = 12) and T-zone lymphoma (TZL) (n = 4). The median patient age was 55 years (range 19-75 years); the male to female ratio was 1.5. 13 patients (52%) had limited stages (I+II), 12 patients (48%) had advanced disease (stage III+IV). 21 patients received the COPBLAM/IMVP-16 regimen. Two patients received more intensive treatments; two received less intensive therapy. Complete remissions were achieved in 16/25 patients (64%). The median observation time of surviving patients was 30 months (range 5-72 months). The actuarial overall survival and event-free survival at 2 years of 21 patients receiving COPBLAM/IMVP-16 were 69% and 35%, respectively. Intensive chemotherapy led to complete remissions in about 60% of the patients and to long-term disease-free survival for one-third. The observed clinical courses illustrate the aggressive nature of PSC, LEL and TZL.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bleomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclophosphamide,
http://linkedlifedata.com/resource/pubmed/chemical/Doxorubicin,
http://linkedlifedata.com/resource/pubmed/chemical/Etoposide,
http://linkedlifedata.com/resource/pubmed/chemical/Ifosfamide,
http://linkedlifedata.com/resource/pubmed/chemical/Methotrexate,
http://linkedlifedata.com/resource/pubmed/chemical/Prednisone,
http://linkedlifedata.com/resource/pubmed/chemical/Procarbazine,
http://linkedlifedata.com/resource/pubmed/chemical/Vincristine
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0007-1048
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
87
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
529-34
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7527646-Adult,
pubmed-meshheading:7527646-Aged,
pubmed-meshheading:7527646-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:7527646-Bleomycin,
pubmed-meshheading:7527646-Cyclophosphamide,
pubmed-meshheading:7527646-Doxorubicin,
pubmed-meshheading:7527646-Etoposide,
pubmed-meshheading:7527646-Female,
pubmed-meshheading:7527646-Humans,
pubmed-meshheading:7527646-Ifosfamide,
pubmed-meshheading:7527646-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:7527646-Lymphoma, Non-Hodgkin,
pubmed-meshheading:7527646-Lymphoma, T-Cell, Peripheral,
pubmed-meshheading:7527646-Male,
pubmed-meshheading:7527646-Methotrexate,
pubmed-meshheading:7527646-Middle Aged,
pubmed-meshheading:7527646-Prednisone,
pubmed-meshheading:7527646-Procarbazine,
pubmed-meshheading:7527646-Prognosis,
pubmed-meshheading:7527646-Prospective Studies,
pubmed-meshheading:7527646-Survival Analysis,
pubmed-meshheading:7527646-Vincristine
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Peripheral T-cell non-Hodgkin's lymphomas of low malignancy: prospective study of 25 patients with pleomorphic small cell lymphoma, lymphoepitheloid cell (Lennert's) lymphoma and T-zone lymphoma. The Kiel Lymphoma Study Group.
|
| pubmed:affiliation |
Universitätsklinikum Rudolf Virchow, Abteilung für Innere Medizin mit Schwerpunkt Hämatologie und Onkologie, Freie Universität Berlin, Germany.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial
|