rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
7
|
pubmed:dateCreated |
1995-1-9
|
pubmed:abstractText |
Elevated concentrations of blood serotonin have been documented in autistic children and mentally retarded adults. Antiserotonergic pharmacotherapy has been partially effective in treating a subgroup of children with autistic disorder. Therefore, the possibility is raised that an antiserotonergic treatment may be of value to adult psychiatric patients with a history of pervasive developmental disorder. Two such cases are described where the patients underwent psychiatric and neuropsychological examination before and after treatment with risperidone, a potent 5-HT2 antagonist with additional D2 antagonistic properties. Particular improvements were documented in both patients, despite long histories of cognitive compromise and high likelihood of damage to the central nervous system.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0706-7437
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
39
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
400-5
|
pubmed:dateRevised |
2011-11-17
|
pubmed:meshHeading |
pubmed-meshheading:7527293-Adolescent,
pubmed-meshheading:7527293-Adult,
pubmed-meshheading:7527293-Antipsychotic Agents,
pubmed-meshheading:7527293-Autistic Disorder,
pubmed-meshheading:7527293-Child,
pubmed-meshheading:7527293-Child Development Disorders, Pervasive,
pubmed-meshheading:7527293-Follow-Up Studies,
pubmed-meshheading:7527293-Humans,
pubmed-meshheading:7527293-Intellectual Disability,
pubmed-meshheading:7527293-Isoxazoles,
pubmed-meshheading:7527293-Male,
pubmed-meshheading:7527293-Neuropsychological Tests,
pubmed-meshheading:7527293-Piperidines,
pubmed-meshheading:7527293-Risperidone,
pubmed-meshheading:7527293-Serotonin,
pubmed-meshheading:7527293-Stereotyped Behavior
|
pubmed:year |
1994
|
pubmed:articleTitle |
Risperidone in the treatment of pervasive developmental disorder.
|
pubmed:affiliation |
Department of Psychiatry, University of Alberta, Edmonton, Canada.
|
pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|