Linked Life Data

7527250

Source:http://linkedlifedata.com/resource/pubmed/id/7527250

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-1-11
pubmed:abstractText
Polymeric matrices that slowly release macromolecules may be useful for the controlled delivery of proteins or polymer-drug conjugates for targeted drug delivery. Solid particles of fluorescein and fluorescently-labeled, size-fractionated dextran (4000-150,000 number average molecular weight) were dispersed in degradable polyanhydride matrices composed of a 1:1 copolymer of fatty acid dimers and sebacic acid. The release of macromolecules from the polymer matrix into buffered saline was measured; changes in the polymer during immersion were monitored by infrared spectroscopy, differential scanning calorimetry, and scanning electron microscopy. Although significant hydrolysis of the polymer occurred within the first day, the matrices remained intact and water-soluble tracers were slowly released for several days. During polymer hydrolysis and erosion, micron-sized pores developed throughout the 2 mm thick polymer matrix, permitting water penetration into the matrix and tracer diffusion out of the matrix. The rate of tracer release from the matrix depended on tracer particle size; rates of fluorescein isothiocyanate dextran release were controlled by adjusting the size of particles dispersed in the matrix.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0920-5063
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
297-311
pubmed:dateRevised
2008-2-20
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Controlled release of macromolecules from a degradable polyanhydride matrix.
pubmed:affiliation
Department of Chemical Engineering, Johns Hopkins University, Baltimore, MD 21218.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.