Linked Life Data

7526882

Source:http://linkedlifedata.com/resource/pubmed/id/7526882

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-1-5
pubmed:abstractText
Pepsinogens are zymogens of pepsins, aspartic proteases working as digestive enzymes in the vertebrate stomach, of which biological and molecular properties have been extensively studied. In developmental biology, pepsinogens offer excellent molecular markers of differentiation of stomach epithelial cells, since their expression is strictly limited to those cells and there are some isozymes that are expressed in developmental stage-specific manner. It is now well established that the expression of embryonic chicken pepsinogen (ECPg) gene is regulated by epithelial-mesenchymal interactions: it is mesenchyme that determines the expression pattern of ECPg along the digestive tract, by supporting or inhibiting the intrinsically endowed ability of epithelial cells to express it. In the present review article, I will describe recent molecular biological and experimental embryological consequences of our studies on the regulation of ECPg expression by mesenchymal cells, with special attention to the nature of mesenchymal factors and the molecular mechanisms of reactivity of epithelial cells to the mesenchymal influences.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0214-6282
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:geneSymbol
ECPg
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
273-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Regulation of pepsinogen gene expression in epithelial cells of vertebrate stomach during development.
pubmed:affiliation
Department of Biology, Faculty of Science, Tokyo Metropolitan University, Japan.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't