| pubmed-article:7526699 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7526699 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:7526699 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:7526699 | lifeskim:mentions | umls-concept:C1413365 | lld:lifeskim |
| pubmed-article:7526699 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7526699 | pubmed:issue | 5 Pt 1 | lld:pubmed |
| pubmed-article:7526699 | pubmed:dateCreated | 1994-12-7 | lld:pubmed |
| pubmed-article:7526699 | pubmed:abstractText | Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) gene, resulting in defective transepithelial Cl- transport. The regulation of CF gene expression is not fully understood. We report that interferon-gamma (IFN-gamma), but not IFN-alpha or -beta, downregulates CFTR mRNA levels in two colon-derived epithelial cell lines, HT-29 and T84, in a time- and concentration (from 0.1 IU/ml)-dependent manner. IFN-gamma has no effect on the transcription rate of the CFTR gene but reduces CFTR mRNA half-life, indicating that it exerts a posttranscriptional regulation of CFTR expression, at least partly, through destabilization of the transcripts. Cells treated with IFN-gamma contain subnormal amounts of 165-kDa CFTR protein. Assays of adenosine 3',5'-cyclic monophosphate-stimulated 36Cl- efflux and whole cell currents show that CFTR function is diminished in IFN-gamma-treated cells. IFN-gamma and tumor necrosis factor-alpha synergistically reduce CFTR gene expression. Our results suggest that production of these cytokines in response to bacterial infections and inflammatory disorders may alter transmembrane Cl- transport. | lld:pubmed |
| pubmed-article:7526699 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7526699 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7526699 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7526699 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7526699 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7526699 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7526699 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7526699 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:7526699 | pubmed:author | pubmed-author:BesançonFF | lld:pubmed |
| pubmed-article:7526699 | pubmed:author | pubmed-author:EdelmanAA | lld:pubmed |
| pubmed-article:7526699 | pubmed:author | pubmed-author:PrzewlockiGG | lld:pubmed |
| pubmed-article:7526699 | pubmed:author | pubmed-author:EscandeDD | lld:pubmed |
| pubmed-article:7526699 | pubmed:author | pubmed-author:BaróII | lld:pubmed |
| pubmed-article:7526699 | pubmed:author | pubmed-author:HongreA SAS | lld:pubmed |
| pubmed-article:7526699 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7526699 | pubmed:volume | 267 | lld:pubmed |
| pubmed-article:7526699 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7526699 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7526699 | pubmed:pagination | C1398-404 | lld:pubmed |
| pubmed-article:7526699 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:7526699 | pubmed:meshHeading | pubmed-meshheading:7526699-... | lld:pubmed |
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| pubmed-article:7526699 | pubmed:meshHeading | pubmed-meshheading:7526699-... | lld:pubmed |
| pubmed-article:7526699 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7526699 | pubmed:articleTitle | Interferon-gamma downregulates CFTR gene expression in epithelial cells. | lld:pubmed |
| pubmed-article:7526699 | pubmed:affiliation | Institut National de la Santé et de la Recherche Médicale Unité 245, Hôpital St.-Antoine, Paris, France. | lld:pubmed |
| pubmed-article:7526699 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7526699 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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