| pubmed-article:7526124 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7526124 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:7526124 | lifeskim:mentions | umls-concept:C0030281 | lld:lifeskim |
| pubmed-article:7526124 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:7526124 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:7526124 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:7526124 | pubmed:dateCreated | 1994-12-5 | lld:pubmed |
| pubmed-article:7526124 | pubmed:abstractText | Using a whole-cell patch-clamp technique, voltage-dependent Ca(2+)-channel activities were found to be increased in cultured single beta cells isolated from neonatally streptozocin-induced diabetic rats (NSZ rats). The current-voltage relationship and inactivation time course of Ba2+ currents via L-type Ca2+ channels were indistinguishable between NSZ and control rats. However, the current density observed in NSZ rats was significantly greater than that in control rats. Ba2+ currents via T-type Ca2+ channels were also found to be enhanced in NSZ beta cells. The insulin-secretory capacity of cultured pancreatic islets in response to a depolarizing stimulus (20 mmol/L arginine or 30 mmol/L KCl) in the presence of 11.1 mmol/L glucose was augmented in NSZ rats, whereas that in response to 11.1 and 16.7 mmol/L glucose alone was significantly reduced. It is concluded that the impaired insulinotropic action of glucose in beta cells in NSZ rats is not due to reduced activity of voltage-dependent Ca2+ channels. The fact that insulin secretion induced by a depolarizing stimulus was enhanced in NSZ rats may be related to the augmented activity of the voltage-dependent calcium current found in NSZ beta cells. | lld:pubmed |
| pubmed-article:7526124 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7526124 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7526124 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7526124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7526124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7526124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7526124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7526124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7526124 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7526124 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7526124 | pubmed:issn | 0026-0495 | lld:pubmed |
| pubmed-article:7526124 | pubmed:author | pubmed-author:IshidaHH | lld:pubmed |
| pubmed-article:7526124 | pubmed:author | pubmed-author:OkadaYY | lld:pubmed |
| pubmed-article:7526124 | pubmed:author | pubmed-author:OkamotoYY | lld:pubmed |
| pubmed-article:7526124 | pubmed:author | pubmed-author:KatoSS | lld:pubmed |
| pubmed-article:7526124 | pubmed:author | pubmed-author:TsujiKK | lld:pubmed |
| pubmed-article:7526124 | pubmed:author | pubmed-author:SeinoYY | lld:pubmed |
| pubmed-article:7526124 | pubmed:author | pubmed-author:HorieMM | lld:pubmed |
| pubmed-article:7526124 | pubmed:author | pubmed-author:TsuuraYY | lld:pubmed |
| pubmed-article:7526124 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7526124 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:7526124 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7526124 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7526124 | pubmed:pagination | 1395-400 | lld:pubmed |
| pubmed-article:7526124 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:7526124 | pubmed:meshHeading | pubmed-meshheading:7526124-... | lld:pubmed |
| pubmed-article:7526124 | pubmed:meshHeading | pubmed-meshheading:7526124-... | lld:pubmed |
| pubmed-article:7526124 | pubmed:meshHeading | pubmed-meshheading:7526124-... | lld:pubmed |
| pubmed-article:7526124 | pubmed:meshHeading | pubmed-meshheading:7526124-... | lld:pubmed |
| pubmed-article:7526124 | pubmed:meshHeading | pubmed-meshheading:7526124-... | lld:pubmed |
| pubmed-article:7526124 | pubmed:meshHeading | pubmed-meshheading:7526124-... | lld:pubmed |
| pubmed-article:7526124 | pubmed:meshHeading | pubmed-meshheading:7526124-... | lld:pubmed |
| pubmed-article:7526124 | pubmed:meshHeading | pubmed-meshheading:7526124-... | lld:pubmed |
| pubmed-article:7526124 | pubmed:meshHeading | pubmed-meshheading:7526124-... | lld:pubmed |
| pubmed-article:7526124 | pubmed:meshHeading | pubmed-meshheading:7526124-... | lld:pubmed |
| pubmed-article:7526124 | pubmed:meshHeading | pubmed-meshheading:7526124-... | lld:pubmed |
| pubmed-article:7526124 | pubmed:meshHeading | pubmed-meshheading:7526124-... | lld:pubmed |
| pubmed-article:7526124 | pubmed:meshHeading | pubmed-meshheading:7526124-... | lld:pubmed |
| pubmed-article:7526124 | pubmed:meshHeading | pubmed-meshheading:7526124-... | lld:pubmed |
| pubmed-article:7526124 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7526124 | pubmed:articleTitle | Increased calcium-channel currents of pancreatic beta cells in neonatally streptozocin-induced diabetic rats. | lld:pubmed |
| pubmed-article:7526124 | pubmed:affiliation | Department of Metabolism and Clinical Nutrition, Kyoto University School of Medicine, Japan. | lld:pubmed |
| pubmed-article:7526124 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7526124 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7526124 | lld:pubmed |
