Linked Life Data

7525921

Source:http://linkedlifedata.com/resource/pubmed/id/7525921

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1994-12-2
pubmed:abstractText
A procedure for estimating the molar water solubility (S) for a series of structurally related drug compounds is presented. HPLC methods for the determination of partition coefficients (P) are combined with semiempirical calculations for S. Multidimensional plots are developed with the physical constants S and P along the x and y axes and with a biological response, e.g. IC50 or ED50, along the z axis. Other attributes, e.g. bioavailability or biodistribution, can be added by color coding, shading, or numbering. Since the methods have a high throughput capability, parameters governing the events leading to pharmacological action [i.e. gastrointestinal dissolution (S), absorption (P), blood level (bioavailability), and biological action (IC50, EC50)] can be correlated for drug series comprising large numbers of compounds.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-3549
pubmed:author
pubmed:issnType
Print
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
948-52
pubmed:dateRevised
2001-11-2
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Estimation and correlation of drug water solubility with pharmacological parameters required for biological activity.
pubmed:affiliation
Department of Biochemistry, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877.
pubmed:publicationType
Journal Article